20.500.12556/RUL-145377 Genetic variability of the vitamin D receptor affects susceptibility to Parkinson's disease and dopaminergic treatment adverse events Vitamin D is a lipid-soluble molecule and an important transcriptional regulator in many tissues and organs, including the brain. Its role has been demonstrated also in Parkinson’s disease (PD) pathogenesis. Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. The aim of this study was to assess the associations of VDR genetic variability with PD risk and different PD-related phenotypes. We genotyped 231 well characterized PD patients and 161 healthy blood donors for six VDR single nucleotide polymorphisms, namely rs739837, rs4516035, rs11568820, rs731236, rs2228570, and rs1544410. We observed that VDR rs2228570 is associated with PD risk (p < 0.001). Additionally, we observed associations of specific VDR genotypes with adverse events of dopaminergic treatment. VDR rs1544410 (GG vs. GA + AA: p = 0.005; GG vs. GA: p = 0.009) was associated with the occurrence of visual hallucinations and VDR rs739837 (TT vs. GG: p = 0.036), rs731236 (TT vs. TC + CC: p = 0.011; TT vs. TC: p = 0.028; TT vs. CC: p = 0.035), and rs1544410 (GG vs. GA: p = 0.014) with the occurrence of orthostatic hypotension. We believe that the reported study may support personalized approach to PD treatment, especially in terms of monitoring vitamin D level and vitamin D supplementation in patients with high risk VDR genotypes. vitamin D receptor Parkinson’s disease biomarker risk susceptibility adverse events vitamin D polymorphism nevrologija Parkinsonova bolezen receptor vitamina D nevroznanost true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-19 15:01:48 2023-04-19 15:01:49 2023-04-20 03:39:14 0000-00-00 00:00:00 2022 0 0 9 str. Vol. 14, art. 853277 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 1663-4365 10.3389/fnagi.2022.853277 101668611 fnagi-14-853277.pdf fnagi-14-853277.pdf 1 C54388CCDE61C42CFE19099F22E0E5FC 872abf4f338812321dda61b709a209fe37b5c27290902e47349754ed7263f4ea a747564d-deb2-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168263 https://www.frontiersin.org/articles/10.3389/fnagi.2022.853277/full 0 53f20e7f-deb2-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168262 Medicinska fakulteta 0 0 0