20.500.12556/RUL-145376 Membrane localization of Piezo1 in the context of its role in the regulation of red blood cell volume Piezo1 is a membrane nonspecific cation channel involved in red blood cells (RBCs) in the regulation of their volume. Recently, it was shown that it is distributed on the RBC membrane in a nonuniform manner. Here it is shown that it is possible to interpret the lateral distribution of Piezo1 molecules on RBC membrane by the curvature dependent Piezo1—bilayer interaction which is the consequence of the mismatch between the intrinsic principal curvatures of the Piezo1 trimer and the principal curvatures of the membrane at Piezo1's location but without its presence. This result supports the previously proposed model for the role of Piezo1 in the regulation of RBC volume. red blood cell volume membrane permeability discocyte lateral distribution membrane curvature channel intrinsic curvature spontaneous curvature volumen rdečih krvnih celic prepustnost membrane diskocit true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-19 14:45:25 2023-04-19 14:45:28 2023-04-20 03:39:14 0000-00-00 00:00:00 2022 0 0 8 str. Vol. 13, art. 879038 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 1664-042X 10.3389/fphys.2022.879038 110843139 fphys-13-879038.pdf fphys-13-879038.pdf 1 6E67B2DE2C244EAB9FE5FA1ECBFC6862 d5d2954637e1e88db30acb40ea070d27656b1e7f9a6b071ec5ac4e06a21762d1 25788d9e-deb0-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168260 https://www.frontiersin.org/articles/10.3389/fphys.2022.879038/full 1 e57a4e97-deaf-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168259 Medicinska fakulteta 0 0 0