20.500.12556/RUL-145325 Vegetable butters and oils as therapeutically and cosmetically active ingredients for dermal use a review of clinical studies While the chemical composition of vegetable butters and oils has been studied in detail, there is limited knowledge about their mechanisms of action after application on the skin. To understand their dermal effects better, 27 clinical studies evaluating 17 vegetable oils (almond, argan, avocado, borage, coconut, evening primrose, kukui, marula, mustard, neem, olive, rapeseed, sacha inchi, safflower, shea butter, soybean and sunflower oils) were reviewed in this research. The reviewed studies focused on non-affected skin, infant skin, psoriasis, xerosis, UVB-induced erythema, atopic dermatitis, molluscum contagiosum, tungiasis, scars, striae and striae gravidarum. We conclude that in inflammation-affected skin, vegetable oils with a high content of oleic acid, together with the lack of or a low linoleic acid content, may cause additional structural damage of the stratum corneum, while oils high in linoleic acid and saturated fatty acids may express positive effects. Non-affected skin, in contrast, may not react negatively to oils high in oleic acid. However, the frequency and duration of an oil’s use must be considered an important factor that may accelerate or enhance the negative effects on the skin’s structural integrity. vegetable butters vegetable oils skin barrier fatty acids infant skin xerosis atopic dermatitis psoriasis rastlinska masla kožna bariera maščobne kisline koža dojenčkov kseroza atopični dermatitis luskavica kozmetika rastlinska olja dermatologija true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-17 15:34:24 2023-04-17 15:34:30 2023-04-18 03:32:57 0000-00-00 00:00:00 2022 0 0 17 str. Vol. 13, art. 868461 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 664.34:665.5 1663-9812 10.3389/fphar.2022.868461 108011011 fphar-13-868461.pdf fphar-13-868461.pdf 1 A632F01E37072158A96CC56F3106A152 1cfb79754cd5ac1e382edae09f6d9db055191fddf7631c3a370cb21073256143 b15fc179-dd24-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168156 https://www.frontiersin.org/articles/10.3389/fphar.2022.868461/full 1 6b8d45c5-dd24-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168155 Fakulteta za farmacijo 0 0 0