20.500.12556/RUL-145248 The influence of diabetic peripheral neuropathy on the duration of sciatic nerve block with 1.3% liposomal bupivacaine and 0.25% bupivacaine hydrochloride in a mouse model Little is known regarding the pharmacological properties of extended-release local anesthetics in the setting of diabetic peripheral neuropathy. We investigated and compared the duration of sciatic nerve block following administration of clinically relevant concentrations of liposomal bupivacaine (LB) and bupivacaine hydrochloride (BH) in diabetic mice with peripheral neuropathy. In this prospective, randomized, and double-blind study, twenty-four female C57BL/6J-OlaHsd mice were assigned to a streptozotocin-induced type 1 diabetes group and a control group without diabetes. The presence of peripheral neuropathy was established by assessing the duration of thermal latency of the plantar and tail-flick tests, following which both groups were subdivided into two subgroups in which 35 mg/kg of 1.31% LB and 7 mg/kg of 0.25% BH were respectively administered for sciatic nerve block. The average sensory block duration with BH was 106 min and 117.1 min in the control and diabetic groups, respectively. With LB, the average sensory block duration was 118 min in the control mice, while in mice with diabetic peripheral neuropathy, the average block duration was significantly longer and above the 270 min limit set in our study. Accordingly, sensory block duration was longer with LB compared to BH, and diabetic peripheral neuropathy significantly increased sciatic nerve block duration with LB. peripheral nerve block local anesthetics liposomal bupivacaine peripheral neuropathy diabetes medicina sladkorna bolezen periferna nevropatija farmakologija anestetiki laboratorijske miši true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-13 15:41:41 2023-04-13 15:41:45 2023-04-14 03:50:00 0000-00-00 00:00:00 2022 0 0 15 str. iss. 9, art. 1824 Vol. 14 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616:615 1999-4923 10.3390/pharmaceutics14091824 119631107 pharmaceutics-14-01824.pdf pharmaceutics-14-01824.pdf 1 F10AD741128181BBCA3B5317000F539A ce7df5a18226112c00ec9f2fceb05337bd036a2df8a75c63e821e51ae9901edc 0c4702a3-da01-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167985 https://www.mdpi.com/1999-4923/14/9/1824 1 c85341da-da00-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167984 Medicinska fakulteta Biotehniška fakulteta 0 0 0