20.500.12556/RUL-145232 Mesenchymal stem/stromal cells may decrease success of cancer treatment by inducing resistance to chemotherapy in cancer cells The tumour microenvironment, which is comprised of various cell types and the extracellular matrix, substantially impacts tumour initiation, progression, and metastasis. Mesenchymal stem/stromal cells (MSCs) are one of the key stromal cells in the tumour microenvironment, and their interaction with cancer cells results in the transformation of naïve MSCs to tumour-associated MSCs. The latter has an important impact on tumour growth and progression. Recently, it has been shown that they can also contribute to the development of chemoresistance in cancer cells. This review provides an overview of 42 studies published between 1 January 2001 and 1 January 2022 that examined the effect of MSCs on the susceptibility of cancer cells to chemotherapeutics. The studies showed that MSCs affect various signalling pathways in cancer cells, leading to protection against chemotherapy-induced damage. Promising results emerged from the use of inhibitors of various signalling pathways that are affected in cancer cells due to interactions with MSCs in the tumour microenvironment. These studies present a good starting point for the investigation of novel treatment approaches and demonstrate the importance of targeting the stroma in the tumour microenvironment to improve treatment outcomes. mesenchymal stem/stromal cells tumour microenvironment cancer therapy tumour stroma cancers drug resistance mezenhimske matične/stromalne celice tumorsko mikrookolje zdravljenje raka true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-13 12:04:29 2023-04-13 12:04:32 2023-04-14 03:49:58 0000-00-00 00:00:00 2022 0 0 35 str. iss. 15, art. 3761 Vol. 14 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 2072-6694 10.3390/cancers14153761 117384707 cancers-14-03761.pdf cancers-14-03761.pdf 1 E86C60377EF360EAE091A95089F47BEC 54a835643dede00499ccfef7c7eff8cfe172f8d3abd891f8d9d64e39c25d9a57 bbdf45aa-d9e2-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167954 https://www.mdpi.com/2072-6694/14/15/3761 1 70270d13-d9e2-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167952 Medicinska fakulteta 0 0 0