20.500.12556/RUL-145191 Integration of androgen hormones in endometrial cancer biology Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In recent years, genomic studies revealed continually evolving mutational landscapes of endometrial tumors that hold great potential for tailoring therapeutic strategies. This review aims to broaden our knowledge of EC biology by focusing on the role of androgen hormones. First, we discuss epidemiological evidence implicating androgens with EC pathogenesis and cover their biosynthesis and metabolism to bioactive 11-oxyandrogens. Next, we explore the endometrial tumor tissue and the altered microbiota as alternative sources of androgens and their 11-oxymetabolites in EC patients. Finally, we discuss the biological significance of androgens' genomic and nongenomic signaling as part of a medley of pathways ultimately deciding the fate of cells. endocrinology endometrial cancer androgen hormones androgen receptor androgens androgen signaling molecular targeted therapy 11-oxyandrogens endokrinologija rak endometrija androgeni hormoni true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-13 09:14:44 2023-04-13 09:14:49 2023-04-14 03:49:43 0000-00-00 00:00:00 2022 0 0 Str. 639-651 no. 9 Vol. 33 Sep. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.1 1043-2760 10.1016/j.tem.2022.06.001 116172547 Integration-of-androgen-hormones-in-endometri_2022_Trends-in-Endocrinology--.pdf Integration-of-androgen-hormones-in-endometri_2022_Trends-in-Endocrinology--.pdf 1 CC931DE0A8926D37BA7B53499F0E5557 8f66a889e91d63f9d80865c2eec84f4b67d44984bb732b352d0e469edc070c90 ed3bb741-d9ca-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167905 https://www.sciencedirect.com/science/article/pii/S1043276022001138 0 e416a5b5-d9ca-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167904 Medicinska fakulteta 0 0 0