20.500.12556/RUL-145165 Relationship between excreted uremic toxins and degree of disorder of children with ASD Autism spectrum disorder (ASD) is a complex developmental disorder in which communication and behavior are affected. A number of studies have investigated potential biomarkers, including uremic toxins. The aim of our study was to determine uremic toxins in the urine of children with ASD (143) and compare the results with healthy children (48). Uremic toxins were determined with a validated high-performance liquid chromatography coupled to mass spectrometry (LC-MS/MS) method. We observed higher levels of p-cresyl sulphate (pCS) and indoxyl sulphate (IS) in the ASD group compared to the controls. Moreover, the toxin levels of trimethylamine N-oxide (TMAO), symmetric dimethylarginine (SDMA), and asymmetric dimethylarginine (ADMA) were lower in ASD patients. Similarly, for pCS and IS in children classified, according to the intensity of their symptoms, into mild, moderate, and severe, elevated levels of these compounds were observed. For mild severity of the disorder, elevated levels of TMAO and comparable levels of SDMA and ADMA for ASD children as compared to the controls were observed in the urine. For moderate severity of ASD, significantly elevated levels of TMAO but reduced levels of SDMA and ADMA were observed in the urine of ASD children as compared to the controls. When the results obtained for severe ASD severity were considered, reduced levels of TMAO and comparable levels of SDMA and ADMA were observed in ASD children. uremic toxins autism spectrum disorder ASD degree of deficit uremični toksini motnje avtističnega spektra MAS stopnja primanjkljaja true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-12 07:53:29 2023-04-12 07:53:34 2023-04-13 03:31:23 0000-00-00 00:00:00 2023 0 0 14 str. iss. 8, art. 7078 Vol. 24 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.896 1422-0067 10.3390/ijms24087078 148468227 ijms-24-07078-v2.pdf ijms-24-07078-v2.pdf 1 FAAFA4E07169B259E35EF983FBDC0ABF fb01a87543d884c9f7180afc2b0b6a10220c95c11477b77b2e63d0aa713adb09 bf8bb961-d8f6-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167853 https://www.mdpi.com/1422-0067/24/8/7078 1 3828daf4-d8f6-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167852 Fakulteta za farmacijo 0 0 0