20.500.12556/RUL-145158 Intra-species variations of bioactive compounds of two dictyota species from the Adriatic Sea antioxidant, antimicrobial, dermatological, dietary, and neuroprotective potential The marine environment has a significant impact on life on Earth. Organisms residing in it are vital for the ecosystem but also serve as an inexhaustible source of biologically active compounds. Herein, the biodiversity of two brown seaweeds, Dictyota dichotoma and Dictyota fasciola from the Adriatic Sea, was evaluated. The aim of the study was the determination of differences in compound composition while comparing their activities, including antioxidant, antimicrobial, and enzyme inhibition, in connection to human digestion, dermatology, and neurological disorders. Chemical analysis revealed several terpenoids and steroids as dominant molecules, while fucoxanthin was the main identified pigment in both algae. D. dichotoma had higher protein, carbohydrate, and pigment content. Omega-6 and omega-3 fatty acids were identified, with the highest amount of dihomo-γ-linolenic acid and α-linolenic acid in D. dichotoma. Antimicrobial testing revealed a dose-dependent inhibitory activity of methanolic fraction against Escherichia coli and Staphylococcus aureus. Moderate antioxidant activity was observed for both algae fractions, while the dietary potential was high, especially for the D. fasciola dichloromethane fraction, with inhibition percentages of around 92% for α-amylase and 57% for pancreatic lipase at 0.25 mg/mL. These results suggest that Dictyota species might be a potent source of naturally derived agents for obesity and diabetes. Dictyota dichotoma Dictyota fasciola brown seaweeds chromatography toxicity proteins carbohydrates amino acids bioactivity Dictyota dichotoma Dictyota fasciola rjave morske alge kromatografija toksičnost beljakovine ogljikovi hidrati aminokisline bioaktivnost true false true Angleški jezik Ni določen Članek v reviji 2023-04-11 12:30:33 2023-04-11 12:30:35 2023-04-14 08:57:58 0000-00-00 00:00:00 2023 0 0 30 str. iss. 4, art. 857 Vol. 12 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2023-01-01 543.544 2076-3921 10.3390/antiox12040857 148389635 Martic-2023-Intra-species-variations-of-bioacti.pdf Martic-2023-Intra-species-variations-of-bioacti.pdf 1 43DB621E4EF4FC73E6F073D505168A25 1e77e90a89889366e5fba5812a825a9bcf566af5c919eabd9e41ef1b8756f37a 10526ed5-d860-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167843 https://www.mdpi.com/2076-3921/12/4/857 1 c09b7174-d853-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167836 Zdravstvena fakulteta 0 0 0