20.500.12556/RUL-145004 Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity Aim: To evaluate the effect of once-weekly subcutaneous semaglutide 1.0 mg on the late digestive period of gastric emptying (GE) after ingestion of a standardized solid test meal by using technetium scintigraphy, the reference method for this purpose. Methods: We conducted a single-blind, placebo-controlled trial in 20 obese women with polycystic ovary syndrome (PCOS; mean [range] age 35 [32.3-40.8] years, body mass index 37 [30.7-39.8] kg/m$^2$) randomized to subcutaneous semaglutide 1.0 mg once weekly or placebo for 12 weeks. GE was assessed after ingestion of [$^{99mT}$c] colloid in a pancake labelled with radiopharmaceutical by scintigraphy using sequential static imaging and dynamic acquisition at baseline and at Week 13. Estimation of GE was obtained by repeated imaging of remaining [$^{99mT}$c] activity at fixed time intervals over the course of 4 hours after ingestion. Results: From baseline to the study end, semaglutide increased the estimated retention of gastric contents by 3.5% at 1 hour, 25.5% at 2 hours, 38.0% at 3 hours and 30.0% at 4 hours after ingestion of the radioactively labelled solid meal. Four hours after ingestion, semaglutide retained 37% of solid meal in the stomach compared to no gastric retention in the placebo group (P = 0.002). Time taken for half the radiolabelled meal to empty from the stomach was significantly longer in the semaglutide group than the placebo group (171 vs. 118 min; P < 0.001). Conclusion: Semaglutide markedly delayed 4-hour GE in women with PCOS and obesity. PCOS obesity semaglutide gastric emptying scintigraphy PCOS debelost semaglutid true false true Angleški jezik Slovenski jezik Članek v reviji 2023-03-29 15:43:07 2023-03-29 15:43:12 2023-03-30 03:29:25 0000-00-00 00:00:00 2023 0 0 Str. 975-984 iss. 4 Vol. 25 Apr. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 1462-8902 10.1111/dom.14944 134184963 Diabetes_Obesity_Metabolism_-_2022_-_Jensterle_-_Semaglutide_delays_4‐hour_gastric_emptying_in_women_with_polycystic_ovary.pdf Diabetes_Obesity_Metabolism_-_2022_-_Jensterle_-_Semaglutide_delays_4‐hour_gastric_emptying_in_women_with_polycystic_ovary.pdf 1 267F062EE5EAEB95B1B92E9FBCF7EC0E 049c8f46299ca3939712d88d10061ac294c8f7aeaf9461219b21088818d9d6c8 db9cd93b-ce37-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167623 https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14944 1 8c1b640a-ce37-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167622 Medicinska fakulteta 0 0 0