20.500.12556/RUL-144314 Deuterated drugs and biomarkers in the COVID-19 pandemic Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan (China) in December 2019, COVID-19 rapidly spread globally, resulting in the COVID-19 pandemic. Carriers of the SARS-CoV-2 can experience symptoms ranging from mild to severe (or no symptoms whatsoever). Although vaccination provides extra immunity toward SARS-CoV-2, there has been an urgent need to develop treatments for COVID-19 to alleviate symptoms for carriers of the disease. In seeking a potential treatment, deuterated compounds have played a critical role either as therapeutic agents or as internal MS standards for studying the pharmacological properties of new drugs by quantifying the parent compounds and metabolites. We have identified >70 examples of deuterium-labeled compounds associated with treatment of COVID-19. Of these, we found 9 repurposed drugs and >20 novel drugs studied for potential therapeutic roles along with a total of 38 compounds (drugs, biomarkers, and lipids) explored as internal mass spectrometry standards. This review details the synthetic pathways and modes of action of these compounds (if known), and a brief analysis of each study. COVID-19 hydrogen isotopes inhibitors metabolism pharmaceuticals COVID-19 izotopi vodika inhibitorji presnova zdravila true false true Angleški jezik Slovenski jezik Članek v reviji 2023-02-14 11:29:22 2023-02-14 11:29:23 2023-02-15 03:40:57 0000-00-00 00:00:00 2022 0 0 Str. 41840-41858 iss. 46 Vol. 7 22 Nov. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.8:546.11 2470-1343 10.1021/acsomega.2c04160 131181827 acsomega.2c04160.pdf acsomega.2c04160.pdf 1 F23C1C6747856A5B6139D594A055AB73 913e23c02d18ac50bab9546b66495d359f6ec44b40cda268f3af3f25b0e2e50c 60f3c350-ac52-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=166560 https://pubs.acs.org/doi/10.1021/acsomega.2c04160 1 20584d7f-ac52-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=166559 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0