20.500.12556/RUL-144280 Optimization of brain tumours irradiation determining the set-up margin The aim of this work was to evaluate whether the excising margin of the clinical tumor volume and planning target volume correspond with calculated radiation margin based on systematic errors, and definition of radiation margins of individual brain lobes. This research was a retrospective cross-sectional study. We checked the systematic errors and calculated their average and the size of radiation margins. The average systematic errors were calculated in four directions: lateral, longitudinal, vertical, and rotation. The largest average systematic error was calculated in the lateral direction in the cerebellar area, and the error was also statistically significant (p < 0.05). In rotational direction we notice the statistically significant difference in frontal lobe (p = 0.037), and cerebellar area (p = 0.002). The largest safety margin, as measured by the average systematic errors, is required for irradiation of the cerebellum. The safety margin size of 6.94 mm was calculated according to the formula of Van Herk. However, the smallest safety margin can be used for irradiation of the occipital lobe of the brain, namely 4.85 mm. The linear regression results that only cerebellar lesions affect lateral displacements. Based on our calculation of the mean systematic errors, we estimate that the clinical target volume – planning target volume safety margin can't be reduced further from the current 5 mm to a size of 3 mm without the use of image guided radiotherapy. brain tumor geometric verification of radiation modern radiation therapy technique radiation treatment margin radiotherapy možganski tumor geometrijska verifikacija obsevanja sodobna tehnika obsevanja rob obsevanja radioterapija true false true Angleški jezik Ni določen Članek v reviji 2023-02-09 10:38:31 2023-02-09 10:38:32 2023-02-10 08:58:26 0000-00-00 00:00:00 2022 0 0 Str. 235-240 no. 3 Vol. 37 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-01-01 616-073:615.849 1451-3994 10.2298/NTRP2203235Z 141099523 RAZ_Zager_Marcius_Valerija_2022.pdf RAZ_Zager_Marcius_Valerija_2022.pdf 1 888036DB5160C0B8399612B723416F70 79a5e8204b672bcb3111d2531bf8fb4e9a9283f6083bf3137ae25599aa5f74d9 3543217f-a85d-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=166499 https://ntrp.vinca.rs/2022_3/Marcius2022_3.html 0 10781d5a-a85f-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=166501 Zdravstvena fakulteta 0 0 0