20.500.12556/RUL-143358 Assessment of Vitamin D status in Slovenian premenopausal and postmenopausal women, Using total, free, and bioavailable 25-hydroxyvitamin D (25(OH)D) The objective of our study was to evaluate vitamin D status and its predictors in Slovenian premenopausal and postmenopausal women. A cross-sectional study was carried out between 1 March 2021 and 31 May 2021. A total of 319 healthy women from the Central Slovenian region aged between 44 and 65 were recruited; 176 were included in the final analysis. The vitamin D status was determined by measuring the total 25-Hydroxycholecalciferol (25(OH)D) concentration, vitamin D binding protein (DBP), and albumin and calculating the bioavailable 25(OH)D and free 25(OH)D. For the calculation of bioavailable and free 25(OH)D, we developed a new online calculator. The Endocrine Society’s thresholds for vitamin D deficiency and insufficiency were used; 29.0% of premenopausal and 24.4% of postmenopausal subjects were found to be vitamin D deficient (total 25(OH)D < 50 nmol/L); 76.8% of the premenopausal and 61.7% of postmenopausal subjects were found to have insufficient levels (total 25(OH)D < 75 nmol/L). Premenopausal women had 11.8% lower total 25(OH)D, 32.2% lower bioavailable 25(OH)D, and 25.2% higher DBP than postmenopausal women. The most important predictors of vitamin D status were vitamin D supplementation and time spent in the sun. Contrary to similar studies, the vitamin D status in Slovenian postmenopausal women was significantly better than in premenopausal women. In postmenopausal women, the measurement of free or bioavailable 25(OH)D instead of the total 25(OH)D could be advantageous. 25(OH)D postmenopausal premenopausal bioavailable 25(OH)D free 25(OH)D online calculator cholecalciferol calcidiol menopause DBP po menopavzi pred menopavzo biorazpoložljiv 25(OH)D prosti 25(OH)D spletni kalkulator holekalciferol kalcidiol true false true Angleški jezik Slovenski jezik Članek v reviji 2022-12-16 11:12:51 2022-12-16 11:12:57 2022-12-17 03:34:54 0000-00-00 00:00:00 2022 0 0 12 str. iss. 24, art. 5349 Vol. 14 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.161.2:618.173 2072-6643 134262787 nutrients-14-05349.pdf nutrients-14-05349.pdf 1 E64A184731480A23DF9E9D0043DC6593 ada0d2385075e54453cf44f7e1ce44b2f698ed656409315f0c9e218bcf1e2a25 4bf24238-7d2a-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=165005 https://www.mdpi.com/2072-6643/14/24/5349 1 0b24b2fb-7d2a-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=165004 Fakulteta za farmacijo Zdravstvena fakulteta Medicinska fakulteta 0 0 0