20.500.12556/RUL-142817 The synthesis of (2R)-aziridine-2-carboxylic acid containing dipeptides Optimized conditions for the synthesis of fully deprotected (2R)-aziridine containing dipeptides are described. Preparation of fully protected N- and C- terminal aziridine containing dipeptides was found to be straightforward and high yielding for the majority of compounds, whereas their full deprotection was possible only for C-terminal analogs. Deprotection of N-terminal derivatives using standard procedures of peptide chemistry was found difficult providing only mixtures of unidentifiable products. The described molecules have potential as building blocks in synthetic chemistry, in the chemical biology arena, as covalent modifiers, and as biomarkers. V prispevku so opisani optimizirani pogoji za sintezo dipeptidov, ki vsebujejo popolnoma odščiten (2R)-aziridin. Priprava popolnoma zaščitenih N- in C- terminalnih dipeptidov, ki vsebujejo aziridin, je enostavna in poteka z visokim izkoristkom za večino spojin, medtem ko je njihova popolna odščita možna le za C-terminalne analoge. Odstranjevanje zaščite z N-terminalnih derivatov z uporabo standardnih postopkov peptidne kemije se je izkazalo kot težko, saj vodi do mešanice nedoločljivih produktov. Opisane molekule imajo velik potencial kot gradniki v sintezni kemiji, na področju kemijske biologije, kot kovalentni modifikatorji in kot biomarkerji. dipeptides aziridines biomarkers warheads antibacterial agents dipeptidi aziridini biomarkerji bojne glave antibakterijska sredstva true false true Angleški jezik Slovenski jezik Članek v reviji 2022-11-28 10:40:50 2022-11-28 10:40:54 2022-11-29 03:25:14 0000-00-00 00:00:00 2022 0 0 Str. 261-270 Vol. 69 no. 2 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 543.645.6.057 1580-3155 10.17344/acsi.2021.6673 108102659 6673-52560-1-PB.pdf 6673-52560-1-PB.pdf 1 FC58031A77E431A3828D621599039BBB 9777fb9ad29a82e4aed2b1f12eb5f60160ce700d287129b519def0fbb8054b66 c3a41163-6f00-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=164313 https://journals.matheo.si/index.php/ACSi/article/view/6673 1 a0175f76-6f00-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=164311 Fakulteta za farmacijo 0 0 0