20.500.12556/RUL-142769 Characterization of the spray droplets and spray pattern by means of innovative optical microscopy measurement method with the high-speed camera Liquid atomization plays an important role in the manufacturing of the pharmaceutical products. It is used in all production steps where liquid is applied. In some productions steps precise control over spraying parameters is essential. These steps include fluid bed granulation, film coating of tablets and pellet coating. Precise atomization of liquids enables control over the granule formation in granulation steps and film formation in coating steps. Atomization process includes breakup of liquid and formation of droplets, which is a complex and important phenomenon that should be carefully evaluated for each particular use. This study focuses on characterization of atomization process by the means of combining high-speed imaging, optical microscopy and continuous backlight illumination together with robust image processing algorithm. With pure water and three different hypromellose (HPMC) polymer dispersions that are frequently used for film coating of solid dosage forms, we successfully measured mean droplet size (Sauter mean diameter between 49 and 413 μm), droplet size distribution and droplet speed (in average 10–46 m/s). It was shown that the shape of cumulative volumetric droplet size distribution can be used to evaluate the successfulness of ligament breakup (i.e., formation of droplets) and by that the spray quality. Moreover, the obtained trends and empirical correlations between droplet size and other process parameters are useful in practice in order to select appropriate settings for optimal coating process parameters. Due to the simplicity of proposed method and data processing, the entire system is potentially suitable for near real-time coating monitoring and for rapid optimization of the atomization process. film coating atomization process image processing microscopy high-speed image acquisition pharmaceutics filmsko oblaganje proces atomizacije strojna obdelava slik mikroskopija hitrotekoče zajemanje slik farmacevtika true false true Angleški jezik Slovenski jezik Članek v reviji 2022-11-24 13:13:27 2022-11-24 13:13:31 2023-01-21 03:45:57 0000-00-00 00:00:00 2022 0 0 8 str. Vol. 629, art. 122412 Dec. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615:66.02 0378-5173 10.1016/j.ijpharm.2022.122412 130835715 1-s2.0-S037851732200967X-main.pdf 1-s2.0-S037851732200967X-main.pdf 1 EC6E6B115161AC173862518367E5C065 4ebe9e088234250edd2cf8e9705ff7eb4ec9e349620419421ad725a8e67fc1f2 f27e75e3-9598-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=165896 https://www.sciencedirect.com/science/article/pii/S037851732200967X 1 47ebf18c-6bf1-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=164243 Fakulteta za strojništvo Fakulteta za farmacijo 0 0 0