20.500.12556/RUL-141919 From cave dragons to genomics advancements in the study of subterranean tetrapods Throughout most of the kingdom Animalia, evolutionary transitions from surface life to a life permanently bound to caves and other subterranean habitats have occurred innumerous times. Not so in tetrapods, where a mere 14 cave-obligate species—all plethodontid and proteid salamanders—are known. We discuss why cave tetrapods are so exceptional and why only salamanders have made the transition. Their evolution follows predictable and convergent, albeit independent pathways. Among the many known changes associated with transitions to subterranean life, eye degeneration, starvation resistance, and longevity are especially relevant to human biomedical research. Recently, sequences of salamander genomes have become available opening up genomic research for cave tetrapods. We discuss new genomic methods that can spur our understanding of the evolutionary mechanisms behind convergent phenotypic change, the relative roles of selective and neutral evolution, cryptic species diversity, and data relevant for conservation such as effective population size and demography. cave adaptation troglomorphism salamanders selection biomedicine prilagoditve na jame troglomorfizem repate dvoživke naravna selekcija biomedicina true false true Angleški jezik Slovenski jezik Članek v reviji 2022-10-11 13:40:05 2022-10-11 13:40:06 2022-11-09 03:54:41 0000-00-00 00:00:00 2022 0 0 Str. 254–266 no. 3 Vol. 72 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 597.94 0006-3568 10.1093/biosci/biab117 88995075 biab117.pdf biab117.pdf 1 517C351936C2A8652F1A208E69D1157F 5c3ab88b555b8195979c42eaf127001df03aea0803a349317d988d3721c577a7 eac60c1d-5f37-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163807 https://academic.oup.com/bioscience/article/72/3/254/6438494 0 9089b064-4959-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163107 Biotehniška fakulteta 0 0 0