20.500.12556/RUL-141914 Efficient synthesis of hydroxy-substituted 2-aminobenzo[d]thiazole-6-carboxylic acid derivatives as new building blocks in drug discovery Benzo[d]thiazole is widely used in synthetic and medicinal chemistry, and it is a component of many compounds and drugs that have several different bioactivities. Herein, we describe an elegant pathway for synthesis of methyl 4- and 5-hydroxy-2-amino-benzo[d]thiazole-6-carboxylates as building blocks that can be substituted at four different positions on the bicycle and thus offer the possibility to thoroughly explore the chemical space around the molecule studied as a ligand for the chosen target. A series of 12 new compounds was prepared using the described methods and Williamson ether synthesis. benzo[d]thiazol medicinal chemistry luciferin sinteza spojin bioaktivne spojine true false true Angleški jezik Slovenski jezik Članek v reviji 2022-10-11 13:01:41 2022-10-11 13:01:43 2022-10-12 03:52:41 0000-00-00 00:00:00 2020 0 0 Str. 8305-8311 iss. 14 Vol. 5 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.4:54:547.7/.8 2470-1343 10.1021/acsomega.0c00768 4897137 acsomega.0c00768.pdf acsomega.0c00768.pdf 1 74759A33BBB207CFC360AAF70D8BC216 31238ea70fb9d11e20c165ef9fd56bfaefd3c2ea44d7553fa2206bdbbbaf1b26 3557e853-4954-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163100 https://pubs.acs.org/doi/pdf/10.1021/acsomega.0c00768 1 0dab5dae-4954-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163099 https://pubs.acs.org/doi/10.1021/acsomega.0c00768 1 0d915107-4954-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163098 Fakulteta za farmacijo 0 0 0