20.500.12556/RUL-141883 Two-decades of successful SAR-grounded stories of the novel bacterial topoisomerase inhibitors (NBTIs) The emergence of bacterial resistance against life-saving medicines has forced the scientific community and pharmaceutical industry to take actions in the quest for novel antibacterials. These should not only overcome the existing bacterial resistance, but also provide at least interim effective protection against emerging bacterial infections. Research into DNA gyrase and topoisomerase IV inhibitors has become a particular focus, with the description of a new class of bacterial topoisomerase type II inhibitors known as "novel bacterial topoisomerase inhibitors" NBTIs. Elucidation of the key structural modifications incorporated into these inhibitors and the impact these can have on their general physicochemical properties are detailed in this review. This defines novel bacterial topoisomerase inhibitors with promising antibacterial activities and potencies, which thus represent one potential example of the future "drugs for bad bugs", as identified by the World Health Organization. DNA gyrase inhibitors antibacterials novel bacterial topoisomerase inhibitors intercalators zaviralci DNA giraze topoizomeraza tip II true false true Angleški jezik Slovenski jezik Članek v reviji 2022-10-10 14:07:11 2022-10-10 14:07:14 2022-10-11 03:49:09 0000-00-00 00:00:00 2020 0 0 Str. 5664-5674 iss. 11 Vol. 63 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.015.8 0022-2623 10.1021/acs.jmedchem.9b01738 4880241 acs.jmedchem.9b01738.pdf acs.jmedchem.9b01738.pdf 1 B7239F2A6EEB238BE4B2BCF505522628 f0b3a2b0baa4f2c024293267d06e9b029e973547e9faa72043fc92e3c0e273ce 38239189-4894-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163033 https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01738 Odprt URL 1 0c0888b3-4894-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163030 https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01738 Odprt dostop 1 0c1fc989-4894-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163031 Fakulteta za farmacijo 0 0 0