20.500.12556/RUL-141867 Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety synthesis, experimental and theoretical characterization and cytotoxic activity In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL$^1$Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L$^1$) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL$^1$(N$_3$)(CH$_3$OH)]BF$_4$ and [ZnL$^1$(N$_3$)$_2$], respectively, while Mn(II) forms a binuclear [Mn$_2$L$^1$$_2$(μ-$_{1,1}$-N$_3$)$_2$(N$_3$)$_2$]·2CH$_3$OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin. baker mangan cink kovinski kompleksi true false true Angleški jezik Slovenski jezik Članek v reviji 2022-10-10 10:13:46 2022-10-10 10:13:47 2022-11-08 03:56:52 0000-00-00 00:00:00 2022 0 0 Str. 185-196 iss. 1 Vol. 51 7 Jan. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 546.3-304.6 1477-9234 10.1039/D1DT03169D 93853699 d1dt03169d.pdf d1dt03169d.pdf 1 1B9A4814510B5C5F00A95408777BDF52 177a8fe3d158ae56dbb1331b5f2b314871780c9fd0679cfb6c9b1933c02a6057 13f4c8d9-5ea7-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163781 https://pubs.rsc.org/en/content/articlelanding/2022/dt/d1dt03169d 1 6fc04ed5-4873-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=163002 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0