20.500.12556/RUL-141228 Nutritional status and health-related quality of life in men with advanced castrate-resistant prostate cancer Despite professional recommendations malnutrition is not adequately addressed in cancer patients. Here, we explored whether nutritional status (NS) is associated with HRQoL in men with metastatic castrate-resistant prostate cancer (mCRPC). Methods: Men with mCRPC enrolled into this prospective observational study were allocated to one of the four NS categories based on clinical, laboratory, and patient self-reported criteria: well-nourished (WN), nutritional risk without criteria for cachexia/sarcopenia (NR), sarcopenia, and cachexia. The HRQoL was evaluated by the Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaire. Association between NS and self-reported HRQoL was sought by the linear regression model, which was adjusted for known prognostic variables and body mass index. Results: Over the period of two years, 141 patients were enrolled. Their median age was 74.1 years (IQR 68.6–79.4 years) and majority of them were minimally symptomatic. Fifty-nine patients (41.8%) were WN, followed by 24 (17%), 42 (29.8%), and 16 (11.4%) patients with NR, sarcopenia, and cachexia, respectively. As compared to WN patients, all three other NS categories were significant negative predictors of HRQoL (P<0.04). Conclusions: Abnormal NS is highly prevalent in men with mCRPC and is negatively associated with their HRQoL, which supports the recommendation for management of malnutrition in these patients. prostate cancer nutritional status quality of life rak prostate prehransko stanje kakovost življenja true false true Angleški jezik Slovenski jezik Članek v reviji 2022-09-26 11:01:13 2022-09-26 11:01:18 2022-09-28 03:20:57 0000-00-00 00:00:00 2022 0 0 Str. 472-481 no. 2 Vol. 74 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 0163-5581 10.1080/01635581.2021.1884731 51943427 Nutritional_Status_and_Health_Related_Quality_of_Life_in_Men_with_Advanced_Castrate_Resistant_Prostate_Cancer.pdf Nutritional_Status_and_Health_Related_Quality_of_Life_in_Men_with_Advanced_Castrate_Resistant_Prostate_Cancer.pdf 1 2E0B1025F7078DB11B3C2C2DE0ED120A 9e5b4652b4c55acf11e67b2c8934047be48459ea43c3dc1ea8259e4c72bf5461 41fb2b2d-3d7a-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=162179 https://www.tandfonline.com/doi/full/10.1080/01635581.2021.1884731 0 2e25cd94-3d7a-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=162178 Medicinska fakulteta 0 0 0