20.500.12556/RUL-141223 Vpliv leptina in adiponektina v humanem mleku na telesno sestavo otrok The effects of human milk leptin and adiponectin on children's body composition V tej magistrski nalogi smo ugotavljali vpliv hormonov leptina in adiponektina v humanem mleku na telesno sestavo otrok. V raziskavi je prostovoljno sodelovalo skupno 294 parov mati – otrok iz Ljubljanske porodnišnice, Univerzitetnega kliničnega centra Ljubljana. Vsebnost hormonov smo ugotavljali v vzorcih materinega mleka, odvzetih mesec po rojstvu. Koncentracijo hormonov smo nato določali s pomočjo encimsko imuno - adsorpcijskih preiskav. Za določanje telesne sestave otrok smo uporabili metodo antropometrije, kar je vključevalo meritve telesne mase in višine oziroma dolžine pri dojenčkih, izračun indeksa telesne mase, merjenje deleža telesne maščobe ter meritev debeline kožnih gub. Vpliv leptina smo potrdili pri z-vrednosti pridobljene mase med rojstvom in prvim letom starosti, vpliv adiponektina pa pri z-vrednostih mase in dolžine ob rojstvu. Prav tako se je za statistično značilno razliko izkazala povezava med koncentracijo adiponektina in dolžine pri enem, treh in šestih mesecih, z-vrednostmi indeksa telesne mase pri šestih mesecih, z-vrednosti dolžine, indeksa telesne mase, odstotka telesne maščobe ter nekaterih debelin kožnih gub pri enem letu, nato pa še pri z-vrednostih višine in debelinah kožnih gub na bicepsu pri treh letih. Po primerjavi z drugimi študijami smo, kar zadeva zgoraj navedene parametre, lahko prišli do nekaterih podobnih ugotovitev, sicer pa so bili nekateri rezultati celo nasprotujoči. V uporabi so namreč različne metode in čas vzorčenja humanega mleka, kar seveda vpliva na dobljene rezultate. Zaključimo lahko, da hormoni v humanem mleku vsekakor vplivajo na telesno sestavo otrok, za razlago jasnega mehanizma in poenotenih ugotovitev, pa so potrebne nadaljnje raziskave. In this master's thesis, we determined the influence of the hormones leptin and adiponectin in human milk on the body composition of children. A total of 294 mother-child pairs from the Ljubljana Maternity Hospital, University Clinical Center Ljubljana voluntarily participated in the research. The hormone content was determined in breast milk samples taken one month after birth. The concentration of hormones was then determined with the help of enzyme-immuno-adsorption tests. To determine the body composition of children, we used the anthropometric method, which included measurements of body weight and height or length in infants, calculation of the body mass index, measurement of the proportion of body fat and measurement of the thickness of skin folds. We confirmed the influence of leptin on the z-value of weight gained between birth and the first year of age, and the influence of adiponectin on the z-values of weight and length at birth. Also, the relationship between adiponectin concentration and length at one, three and six months, z-values of body mass index at six months, z-values of length, body mass index, body fat percentage and some skinfold thicknesses proved to be statistically significant. at one year, and then at the z-values of height and bicep skinfold thicknesses at three years. After comparing with other studies, we were able to reach some similar conclusions regarding the above mentioned parameters, but otherwise some results were even contradictory. Namely, different methods and time of sampling human milk are in use, which of course affects the results obtained. We can conclude that the hormones in human milk definitely affect the body composition of children, but further research is needed to explain a clear mechanism and unified findings. telesna sestava otrok humano mleko hormoni v humanem mleku leptin adiponektin dojenje antropometrične meritve child body composition human milk hormones in human milk leptin adiponectin breast feeding antropometric measurements true false false [U. Vide] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2022-09-26 10:11:41 2022-09-26 10:11:49 2022-09-28 03:18:38 0000-00-00 00:00:00 2022 0 Ljubljana 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 613.287-053.2:612.018:572.087 212839 122939651 28133.pdf 28133.pdf 1 CF5569F760D22E1C2EA1C74228D25FA4 634e4189d8ab53e6766db52a6ee02ff9cc05687d1b038cb83e84e441cd1736dc de46e1d4-3d72-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=162170 Biotehniška fakulteta 0 0 0