20.500.12556/RUL-140821 How early maternal deprivation changes the brain and behavior? Early life stress can adversely influence brain development and reprogram brain function and consequently behavior in adult life. Adequate maternal care in early childhood is therefore particularly important for the normal brain development, and adverse early life experiences can lead to altered emotional, behavioral, and neuroendocrine stress responses in the adulthood. As a form of neonatal stress, maternal deprivation/separation is often used in behavioral studies to examine the effects of early life stress and for modeling the development of certain psychiatric disorders and brain pathologies in animal models. The temporary loss of maternal care during the critical postpartum periods remodels the offspring's brain and provokes long-term effects on learning and cognition, the development of mental disorders, aggression, and an increased tendency for the drug abuse. Early life stress through maternal deprivation affects neuroendocrine responses to stress in adolescence and adulthood by dysregulating the hypothalamic–pituitary–adrenal axis and permanently disrupts stress resilience. In this review, we focused on how improper maternal care during early postnatal life affects brain development resulting in modified behavior later in life. behavior brain development maternal deprivation programming stress true false true Angleški jezik Ni določen Članek v reviji 2022-09-19 08:44:18 2022-09-19 08:44:19 2022-09-20 04:04:38 0000-00-00 00:00:00 2022 0 0 Str. 2058-2075 no. 9/10 Vol. 55 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-01-01 612 1460-9568 10.1111/ejn.15238 64141571 how-majdic.pdf how-majdic.pdf 1 07B35EDE80E50665B7D2EFF60CED129A 1871054f786919605f1b4161cbfe13ae58ede2cd6ac92b7c3384d5e294addb52 1921edbe-37e8-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=161622 https://onlinelibrary.wiley.com/doi/10.1111/ejn.15238 1 68fc86b4-37e6-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=161619 Veterinarska fakulteta 0 0 0