20.500.12556/RUL-139993 Sinteza bifenilnih derivatov z zanimivimi solvatokromnimi lastnostmi Synthesis of biphenyl-based derivatives with interesting solvatochromic properties Sintetiziranih, izoliranih in karakteriziranih je bilo šest novih bifenilnih spojin na osnovi analoga [18F]FDDNP z vsebovanim push-pull sistemom. Njihovi raznoliki optični spektri, pripadajoči kvantni izkoristki in absorpcijski koeficienti izkazujejo izjemen vpliv elektron-privlačnih skupin na optične lastnosti molekulskih sond. Ugoden batokromni premik absorpcijskega in emisijskega maksimuma sintetiziranih molekul je zaželjen pri detekciji proteinskih agregatov, povezanih z Alzheimerjevo boleznijo, s fluorescenčno mikroskopijo, saj omogoča manjšo lastno fluorescenco. Poleg tega njihov velik Stokesov premik povečuje razmerje signal/šum med detekcijo. Ugodne optične lastnosti molekul skupaj z njihovo paličasto obliko nakazujejo njihovo potencialno uspešno uporabo v diagnostiki Alzheimerjeve bolezni. In this work we successfully synthesized, isolated and characterized six new biphenyl compounds based on the [18F]FDDNP analogue, containing a push-pull system. Their diverse optical spectra, quantum yields, and molar absorptivity demonstrate the extraordinary influence of electron-withdrawing groups on the optical properties of molecular probes. Synthesized probes exhibit a favorable bathochromic shift of the absorption and emission maxima, allowing for less autofluorescence in the detection of protein aggregates connected to Alzheimer’s disease using the fluorescence microscopy analysis. Furthermore, their large Stokes shifts increases the signal-to-noise ratio during the detection. The favorable optical properties of the synthesized molecules, together with their rod-like shape, suggest their potentially successful use in the diagnosis of Alzheimer’s disease. sinteza optične lastnosti bifenilni analogi fluorescenca synthesis optical properties biphenyl derivatives fluorescence true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2022-09-09 09:30:00 2022-09-09 09:30:02 2022-11-18 09:50:16 0000-00-00 00:00:00 2022 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 22014 129913603 Kulasic_Ines_-_Sinteza_bifenilnih_derivatov_z_zanimivimi_solvatokromnimi_lastnostmi.pdf Kulasic_Ines_-_Sinteza_bifenilnih_derivatov_z_zanimivimi_solvatokromnimi_lastnostmi.pdf 1 8A69E1F5CE0A1C832B34AC04C67C2ED6 19b9e5ddd321d1fae3c4096cbb76054c75e5b812478efcaad76f764236aff38f 2a30ac50-3011-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=160647 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0