20.500.12556/RUL-139768 Metabolic brain pattern in dementia with Lewy bodies relationship to Alzheimer’s disease topography Purpose: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, that shares clinical and metabolic similarities with both Alzheimer’s and Parkinson’s disease. In this study we aimed to identify a DLB-related pattern (DLBRP), study its relationship with other metabolic brain patterns and explore its diagnostic and prognostic value. Methods: A cohort of 79 participants with DLB, 63 with dementia due to Alzheimer’s disease (AD) and 41 normal controls (NCs) and their 2-[$^{18}$F]FDG PET scans were analysed for identification and validation of DLBRP. Voxel-wise correlation and multiple linear regression were used to study the relation between DLBRP and Alzheimer’s disease-related pattern (ADRP), Parkinson’s disease-related pattern (PDRP) and PD-related cognitive pattern (PDCP). Diagnostic and prognostic value of DLBRP and of modified DLBRP after accounting for ADRP overlap (DLBRP ⊥ ADRP), were explored. Results: The newly identified DLBRP shared topographic similarities with ADRP (R$^2$ = 24%) and PDRP (R$^2$ = 37%), but not with PDCP. We could accurately discriminate between DLB and NC (AUC = 0.99) based on DLBRP expression, and between DLB and AD (AUC = 0.87) based on DLBRP ⊥ ADRP expression. DLBRP expression correlated with cognitive impairment, but the correlation was lost after accounting for ADRP overlap. DLBRP and DLBRP ⊥ ADRP correlated with patients’ survival time. Conclusion: DLBRP has proven to be a specific metabolic brain biomarker of DLB, sharing similarities with ADRP and PDRP, but not PDCP. We observed a similar metabolic mechanism underlying cognitive impairment in DLB and AD. DLB-specific metabolic changes were more detrimental for overall survival. dementia with Lewy bodies Alzheimer’s disease biomarker metabolic brain imaging FDG PET network analysis scaled subprofile model/principal component analysis SSM/PCA nevrologija demenca Lewyjeva telesca alzheimerjeva bolezen nevrodegenerativne bolezni true false true Angleški jezik Slovenski jezik Članek v reviji 2022-09-07 08:36:55 2022-09-07 08:36:56 2022-09-16 04:11:55 0000-00-00 00:00:00 2022 0 0 10 str. Vol. 35, art. 103080 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2213-1582 10.1016/j.nicl.2022.103080 113110787 1-s2.0-S2213158222001450-main.pdf 1-s2.0-S2213158222001450-main.pdf 1 F9BAEF0637B046EA7B4083982A98E878 19a230534741c856e9f9fbc581e8d90d671b77eada518de923b098c3895b9a93 b70c6f8a-2e77-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=160382 https://www.sciencedirect.com/science/article/pii/S2213158222001450 0 6ae020a4-2e77-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=160381 Medicinska fakulteta 0 0 0