20.500.12556/RUL-139678 Comparison of ADVIA Centaur ultra-sensitive and high-sensitive assays for troponin I in serum Cardiac troponin I (cTnI) is a standard biomarker for the diagnosis of acute myocardial infarction (AMI). While older, ultra-sensitive cTnI (us-cTnI) assays use the 99th percentile as the reference threshold, newer high-sensitive cTnI (hs-cTnI) assays use the limit of detection or functional sensitivity instead. However, little has been done to systematically compare these two methods. The present study also served as a validation of hs-cTnI in our laboratory. Here, we compared the results obtained from the blood serum obtained from 8810 patients using the us-cTnI and the hs-cTnI assays run in tandem on the ADVIA Centaur XP analyser. We found that in 2279 samples the concentration of cTnI measured with the ultra-sensitive method was below the detection limit, while with the high-sensitive method, only 540 were below the detection limit. We also compared results from these assays with the ultimate diagnosis of a subset of individuals. The analysis of the results below cut-off with the ultra-sensitive method showed that this method would not detect 96 cases related to heart disorder. Overall, the main finding of our research is that hs-cTnI is the preferable option and is able to be deployed effectively in the laboratory setting. acute coronary syndrome myocardial infarction troponin I verification verifikacija troponin I miokardni infarkt akutni koronarni sindrom klinična kemija true false true Angleški jezik Slovenski jezik Članek v reviji 2022-09-06 09:48:31 2022-09-06 09:48:34 2022-09-16 04:11:37 0000-00-00 00:00:00 2022 0 0 6 str. art. e00293 Vol. 31 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-074:616.127-005.8+616.132.2 2352-5517 10.1016/j.plabm.2022.e00293 115290371 1-s2.0-S2352551722000324-main.pdf 1-s2.0-S2352551722000324-main.pdf 1 D7D34255E1ED79487A6313BF34F1DEF1 9649b808b3da11688182d0086edf4dd0b2f3628a9b9822aff95b0f03ef4d4dc1 9d186d19-2db8-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=160275 https://www.sciencedirect.com/science/article/pii/S2352551722000324 0 42ab9ff8-2db8-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=160272 Fakulteta za farmacijo Medicinska fakulteta 0 0 0