20.500.12556/RUL-139600 Interactions of (−)-epigallocatechin-3-gallate with model lipid membranes (−)-Epigallocatechin-3-gallate (EGCG) is a flavonoid known for its good antioxidant potential and health benefits. It is one of the most intriguing flavonoids, especially because of its specific interactions with model lipid membranes. It was noticed that EGCG might form EGCG rich domains/rafts at certain compositions of lipid membranes. In this article, we investigate whether EGCG forms EGCG rich domains when incorporated in 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) liposomes. Our results show that EGCG decreases lipid ordering parameter in ordered membranes and increases it in the case of disordered ones. Also, incorporation of EGCG does not affect the zeta-potential and shape of the liposomes, but it can induce aggregation of liposomes. Our study also demonstrates that liposomes with incorporated EGCG are highly protected against UV-light induced oxidation. aggregation liposome size liposome shape ultraviolet radiation DSC ITC lipid-order parameter modelne membrane fenolne spojine epigalokatehin epigalokatehin-3-galat interakcije true false true Angleški jezik Slovenski jezik Članek v reviji 2022-09-05 13:49:13 2022-09-05 13:49:13 2022-09-16 04:11:20 0000-00-00 00:00:00 2022 0 0 13 str. iss. 10, art. 183999 Vol. 1864 Oct. 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.352+577.1:547.56 0005-2736 10.1016/j.bbamem.2022.183999 112544771 1-s2.0-S0005273622001377-main.pdf 1-s2.0-S0005273622001377-main.pdf 1 658604A5F156B14562E4B92012B87282 a1d7d3c61c2fefd5d84e2d780ed8ff3b9a46990f2f25c34d09be32d71d974fe0 0c772ffc-2d11-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=160184 https://www.sciencedirect.com/science/article/pii/S0005273622001377 0 b7142b95-2d10-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=160183 Biotehniška fakulteta 0 0 0