20.500.12556/RUL-139098 Sinteza nekaterih metil 1-aril-3-hidroksi-1H-pirazol-4-karboksilatov Synthesis of some methyl 3-hydroxy-1-phenyl-1H-pyrazole-4-carboxylates V diplomskem delu sem se ukvarjala s sintezo spojin, pirazolovih derivatov, ki so že bili preučevani kot potencialni antimalariki. Spojine sem pripravila po postopku iz literature. Uspešno sem pripravila hidrazide metil malonata iz metil malonil klorida in derivatov hidrazina, kar sem potrdila z IR in NMR spektroskopijo. V drugi stopnji sem dobljene hidrazide kondenzirala z amid acetalom in jih nato ciklizirala v pirazole. S pomočjo IR in NMR spektroskopije sem dokazala, da sem uspešno sintetizirala želene produkte. Testirali smo biološko aktivnost produktov s standardiziranimi encimskimi testi, ki pa so na žalost pokazali, da spojine nimajo pričakovanega inhibitornega učinka na encim PfDHODH. In diploma work, I dealt with the synthesis of compounds, pyrazole derivatives, which have already been studied as potential antimalarials. I prepared the compounds according to the procedure from the literature. I successfully prepared methyl malonate hydrazide derivates from methyl malonyl chloride and hydrazine derivatives, which was confirmed by IR and NMR spectroscopy. In the second step, I condensed the obtained hydrazides with amide acetal and then cyclized them into pyrazoles. Using IR and NMR spectroscopy, I proved that I had successfully synthesized the desired products. We tested the biological activity of the products with standardized enzyme tests, which unfortunately showed that the compounds did not have the expected inhibitory effect on the PfDHODH enzyme. antimalariki pirazoli inhibitorji PfDHODH encimski testi antimalarials pyrazoles inhibitors PfDHODH enzyme tests true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2022-08-30 15:05:00 2022-08-30 15:05:03 2022-09-21 12:47:19 0000-00-00 00:00:00 2022 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 21810 122287107 Jurajevcic_Manca_-_Sinteza_nekaterih_metil_1-aril-3-hidroksi-1H-pirazol-4-karboksilatov.pdf Jurajevcic_Manca_-_Sinteza_nekaterih_metil_1-aril-3-hidroksi-1H-pirazol-4-karboksilatov.pdf 1 BC0A123AF5E21277A9B6B2C5047B62C3 570b3dc03b3ec4abd7573f0ed8de478c6e2289259f228e6779272c866b8ab998 53e12395-2864-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159633 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0