20.500.12556/RUL-139091 Influence of the binder jetting process parameters and binder liquid composition on the relevant attributes of 3D-printed tablets Binder jetting has the potential to revolutionize the way we produce medicine. However, tablets produced by binder jetting technology can be quite fragile and hard to handle. In this study, the printing process and ink composition were examined to optimize the mechanical properties of tablets. A model formulation containing the ketoprofen drug was developed and used as a base for optimization. Firstly, important printing parameters were identified with a fractional factorial design. Saturation and layer height critically influenced selected tablet properties. Relevant process parameters were optimized for tablet mechanical strength by using the D-optimization DoE approach. The best mechanical properties were achieved when saturation was set to 1 and layer height to 150 µm. On the other hand, binder ink composition did not appear to impact tablet mechanical strength as much as process parameters did. Three ethanol-water mixtures were tested at three tablet strength levels and no definitive conclusions could be drawn. The binder jetting process can be wasteful, especially if the unbound powder cannot be reused. To determine the suitability of powder blend recycling, the ketoprofen content was measured for 27 subsequent batches of tablets. While the trendline did indicate a slight reduction in ketoprofen content, the powder blend reuse can nevertheless be employed. binder jetting design of experiments 3D-printed tablets mechanical properties printer development ketoprofen brizganje veziva načrtovanje poskusov 3D-natisnjene tablice mehanske lastnosti razvoj tiskalnikov ketoprofen tablete farmacevtska industrija true false true Angleški jezik Slovenski jezik Članek v reviji 2022-08-30 13:06:19 2022-08-30 13:06:25 2023-05-17 03:56:41 0000-00-00 00:00:00 2022 0 0 21 str. iss. 8, art. 1568 Vol. 14 2022 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 661.12:615.454 1999-4923 10.3390/pharmaceutics14081568 119609859 pharmaceutics-14-01568-v2.pdf pharmaceutics-14-01568-v2.pdf 1 9F35831D8E8E62E23EB84A605F854830 e6dba60df73c6839299000bf9b1cabea6f247ad1e73e39fb730f8f5966a4b691 19b621d0-2854-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159624 https://www.mdpi.com/1999-4923/14/8/1568 1 c1c5b10c-2853-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159623 Fakulteta za farmacijo 0 0 0