20.500.12556/RUL-138917 Current uncertainties and future challenges regarding NAD+ boosting strategies Precursors of nicotinamide adenine dinucleotide (NAD+), modulators of enzymes of the NAD+ biosynthesis pathways and inhibitors of NAD+ consuming enzymes, are the main boosters of NAD+. Increasing public awareness and interest in anti-ageing strategies and health-promoting lifestyles have grown the interest in the use of NAD+ boosters as dietary supplements, both in scientific circles and among the general population. Here, we discuss the current trends in NAD+ precursor usage as well as the uncertainties in dosage, timing, safety, and side effects. There are many unknowns regarding pharmacokinetics and pharmacodynamics, particularly bioavailability, metabolism, and tissue specificity of NAD+ boosters. Given the lack of long-term safety studies, there is a need for more clinical trials to determine the proper dose of NAD+ boosters and treatment duration for aging prevention and as disease therapy. Further research will also need to address the long-term consequences of increased NAD+ and the best approaches and combinations to increase NAD+ levels. The answers to the above questions will contribute to the more efficient and safer use of NAD+ boosters. nicotinamide adenine dinucleotide NAD+ NAD+ boosters NAD+ precursors safety side effects nikotinamid adenin dinukleotid NAD+ NAD+ ojačevalci prekurzorji NAD+ varnost stranski učinki true false true Angleški jezik Ni določen Članek v reviji 2022-08-25 09:17:18 2022-08-25 09:17:22 2022-09-15 04:17:25 0000-00-00 00:00:00 2022 0 0 18 str. iss. 9, art. 1637 Vol. 11 2022 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 2022-08-24 613.98:616-092:66.094.3.097.8 2076-3921 10.3390/antiox11091637 119104771 Poljsak-2022-Current-uncertainties-and-future-ch_(1).pdf Poljsak-2022-Current-uncertainties-and-future-ch_(1).pdf 1 0E1CB42D153AD9E650833D67E9EE25A0 7f80da4bba2d8244a6d7aca4a761bc97d32b425fc6c107b8b0b1d7794fa4b3bf 81a4da34-2446-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159414 https://www.mdpi.com/2076-3921/11/9/1637 1 f119c4ce-2445-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159413 Zdravstvena fakulteta Medicinska fakulteta 0 0 0