20.500.12556/RUL-138883 Neuroepigenetics of psychiatric disorders focus on lncRNA Understanding the pathology of psychiatric disorders is challenging due to their complexity and multifactorial origin. However, development of high-throughput technologies has allowed for better insight into their molecular signatures. Advancement of sequencing methodologies have made it possible to study not only the protein-coding but also the noncoding genome. It is now clear that besides the genetic component, different epigenetic mechanisms play major roles in the onset and development of psychiatric disorders. Among them, examining the role of long noncoding RNAs (lncRNAs) is a relatively new field. Here, we present an overview of what is currently known about the involvement of lncRNAs in schizophrenia, major depressive and bipolar disorders, as well as suicide. The diagnosis of psychiatric disorders mainly relies on clinical evaluation without using measurable biomarkers. In this regard, lncRNA may open new opportunities for development of molecular tests. However, so far only a small set of known lncRNAs have been characterized at molecular level, which means they have a long way to go before clinical implementation. Understanding how changes in lncRNAs affect the appearance and development of psychiatric disorders may lead to a more classified and objective diagnostic system, but also open up new therapeutic targets for these patients. long noncoding RNA schizophrenia depression suicide bipolar disorder dolgo nekodirana RNA shizofrenija depresija true false true Angleški jezik Slovenski jezik Članek v reviji 2022-08-24 11:58:36 2022-08-24 11:58:41 2022-09-15 04:17:20 0000-00-00 00:00:00 2021 0 0 13 str. Vol. 149, art. 105140 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.89 1872-9754 10.1016/j.neuint.2021.105140 71511555 1-s2.0-S0197018621001868-main.pdf 1-s2.0-S0197018621001868-main.pdf 1 8101CB5C6DBA15EE37F2BA8D9408C38A e79ab113ed7876b124a09dd4582f289baf3259ca44bbba22ac9490005f3f8f5e 9e1df860-2393-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159373 https://www.sciencedirect.com/science/article/pii/S0197018621001868 1 4f691637-2393-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159371 Medicinska fakulteta 0 0 0