20.500.12556/RUL-138758 Interactome of PTH-Regulated miRNAs and their predicted target genes for Investigating the epigenetic effects of PTH (1–34) in bone metabolism Osteoporosis is a metabolic bone disease that mostly affects the elderly. A lot of drugs are available, mostly with an antiresorptive effect but just a few with an osteoanabolic effect, meaning they promote bone building. PTH (1-34) or teriparatide is an osteoanabolic drug, but its efficacy varies between individuals. We performed a literature review and extracted a dataset of 62 microRNAs (miRNAs) from 10 different studies; predicted miRNA target interactions (MTIs) were obtained with the help of four software tools: DIANA, miRWalk, miRDB and TargetScan. With the construction of an interactome of PTH-regulated miRNAs and their predicted target genes, we elucidated miR-146a-5p, miR-551b-5p, miR-205-3p, miR-33a-3p, miR-338-5p as miRNAs with the most interactions and miR-410-3p as the miRNA targeting bone-related pathways with the highest significance. These miRNAs could help in further understanding the mechanism of action of PTH on bone metabolism and osteoporosis. They also have the potential for novel network-based biomarkers for osteoporosis treatment efficacy and safety and as new therapeutic targets. osteoporosis osteoporosis treatment microRNA parathyroid hormone teriparatide network Cytoscape biological pathway gene enrichment biomarker zdravljenje osteoporoze mikroRNA paratiroidni hormon teriparatid omrežje biomarker za obogatitev genov biološka pot true false true Angleški jezik Slovenski jezik Neznano 2022-08-16 10:44:53 2022-08-16 10:45:04 2022-09-15 04:17:08 0000-00-00 00:00:00 2022 0 0 Str. 1-15 iss. 8, art. 1443 Vol. 13 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-08-13 616.71-007.234:616-085 2073-4425 10.3390/genes13081443 118226947 https://www.mdpi.com/2073-4425/13/8/1443 1 b88c0740-1d3f-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159194 genes-13-01443.pdf genes-13-01443.pdf 1 11AEA578AD16B4EE294E40C81CB42B23 315feb0f40a1570539733ed6b394faee2cd3ea07ee27f78c5080fb891db5d745 4675f627-1d40-11ed-92af-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159195 Fakulteta za farmacijo 0 0 0