20.500.12556/RUL-138698 Cytoskeletal proteins as glioblastoma biomarkers and targets for therapy a systematic review Glioblastoma, the most common primary brain malignancy, is an exceptionally fatal cancer. Lack of suitable biomarkers and efficient treatment largely contribute to the therapy failure. Cytoskeletal proteins are crucial proteins in glioblastoma pathogenesis and can potentially serve as biomarkers and therapeutic targets. Among them, GFAP, has gained most attention as potential diagnostic biomarker, while vimentin and microtubules are considered as prospective therapeutic targets. Microtubules represent one of the best anti-cancer targets due to their critical role in cell proliferation. Despite testing in clinical trials, the efficiency of taxanes, epothilones, vinca-domain binding drugs, colchicine-domain binding drugs and γ-tubulin binding drugs remains to be confirmed. Moreover, tumor treating field that disrupts microtubules draw attention because of its high efficiency and is called “the fourth cancer treatment modality”. Thereby, because of the involvement of cytoskeleton in key physiological and pathological processes, its therapeutic potential in glioblastoma is currently extensively investigated. cytoskeleton glioblastoma biomarkers glioblastoma therapy vimentin microtubules citoskelet glioblastom označevalci true false true Angleški jezik Slovenski jezik Članek v reviji 2022-08-09 15:17:52 2022-08-09 15:17:57 2022-09-15 04:17:04 0000-00-00 00:00:00 2021 0 0 13 str. Vol. 160, art. 103283 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1879-0461 10.1016/j.critrevonc.2021.103283 54458627 1-s2.0-S1040842821000718-main.pdf 1-s2.0-S1040842821000718-main.pdf 1 26112F1A12237CF9B04EFEF5AE24B6C6 64ee4f3ef9c191a7eab56582cc8182e55bbbfffe3ffb2f95c6f14573b67b4ef5 af09d386-17e6-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159107 https://www.sciencedirect.com/science/article/pii/S1040842821000718 0 654df246-17e5-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159106 Medicinska fakulteta 0 0 0