20.500.12556/RUL-138683 A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy Background: Machine learning (ML) and artificial intelligence are emerging as important components of precision medicine that enhance diagnosis and risk stratification. Risk stratification tools for hypertrophic cardiomyopathy (HCM) exist, but they are based on traditional statistical methods. The aim was to develop a novel machine learning risk stratification tool for the prediction of 5-year risk in HCM. The goal was to determine if its predictive accuracy is higher than the accuracy of the state-of-the-art tools. Method: Data from a total of 2302 patients were used. The data were comprised of demographic characteristics, genetic data, clinical investigations, medications, and disease-related events. Four classification models were applied to model the risk level, and their decisions were explained using the SHAP (SHapley Additive exPlanations) method. Unwanted cardiac events were defined as sustained ventricular tachycardia occurrence (VT), heart failure (HF), ICD activation, sudden cardiac death (SCD), cardiac death, and all-cause death. Results: The proposed machine learning approach outperformed the similar existing risk-stratification models for SCD, cardiac death, and all-cause death risk-stratification: it achieved higher AUC by 17%, 9%, and 1%, respectively. The boosted trees achieved the best performing AUC of 0.82. The resulting model most accurately predicts VT, HF, and ICD with AUCs of 0.90, 0.88, and 0.87, respectively. Conclusions: The proposed risk-stratification model demonstrates high accuracy in predicting events in patients with hypertrophic cardiomyopathy. The use of a machine-learning risk stratification model may improve patient management, clinical practice, and outcomes in general. hypertrophic cardiomyopathy risk stratification machine learning artificial intelligence hipertrofična kardiomiopatija napovedovanje tveganja strojno učenje umetna inteligenca true false true Angleški jezik Slovenski jezik Članek v reviji 2022-08-09 12:08:44 2022-08-09 12:08:46 2022-09-15 04:17:03 0000-00-00 00:00:00 2021 0 0 9 str. Vol. 135, art. 104648 Aug. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 004.8:616.12-008.46 0010-4825 10.1016/j.compbiomed.2021.104648 71489795 1-s2.0-S001048252100442X-main.pdf 1-s2.0-S001048252100442X-main.pdf 1 C4B304E87AAF7747E4BC442E5DD5BC3A e30c1ca8e2db13d1300d651c362a952d03110134bf48062423b5718515a48d3d 4622d862-17cb-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159083 https://www.sciencedirect.com/science/article/pii/S001048252100442X 1 f7bddd2a-17ca-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159082 Fakulteta za računalništvo in informatiko 0 0 0