20.500.12556/RUL-138669 Cell death due to electroporation a review Exposure of cells to high voltage electric pulses increases transiently membrane permeability through membrane electroporation. Electroporation can be reversible and is used in gene transfer and enhanced drug delivery but can also lead to cell death. Electroporation resulting in cell death (termed as irreversible electroporation) has been successfully used as a new non-thermal ablation method of soft tissue such as tumours or arrhythmogenic heart tissue. Even though the mechanisms of cell death can influence the outcome of electroporation-based treatments due to use of different electric pulse parameters and conditions, these are not elucidated yet. We review the mechanisms of cell death after electroporation reported in literature, cell injuries that may lead to cell death after electroporation and membrane repair mechanisms involved. The knowledge of membrane repair and cell death mechanisms after cell exposure to electric pulses, targets of electric field in cells need to be identified to optimize existing and develop of new electroporation-based techniques used in medicine, biotechnology, and food technology. apoptosis cell death cell injury electroporation membrane repair necroptosis necrosis pyroptosis apoptoza celična smrt poškodba celice elektroporacija celjenje membrane nekroptoza nekroza piroptoza true false true Angleški jezik Slovenski jezik Članek v reviji 2022-08-08 15:12:33 2022-08-08 15:12:34 2022-09-15 04:17:02 0000-00-00 00:00:00 2021 0 0 18 str. art. 107871 Vol. 141 Oct. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577:602.621 1567-5394 10.1016/j.bioelechem.2021.107871 69133827 1-s2.0-S1567539421001341-main.pdf 1-s2.0-S1567539421001341-main.pdf 1 2ABF8252BF03BE0EA0607EB1DF2F1A7A da98cdaaa4d4c0f4f9f0dc7e00bb5db608c72611bea3c019ed04aebbbddfc9a5 f42c2bfd-171b-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159057 https://www.sciencedirect.com/science/article/pii/S1567539421001341 0 7aecfdd4-171b-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=159056 Fakulteta za elektrotehniko 0 0 0