20.500.12556/RUL-138433 Complex osteochondral lesions of the talus treated with a novel bi-phasic aragonite-based implant To present initial results of a novel, bi-phasic, porous, biodegrade, and cell-free aragonite-based scaffold for treating complex osteochondral lesions of the talus (OLT). Four subjects (2 males and 2 females; 34-61 years old) were operated on their ankles due to chronic and deep OLT-Hepple grades 4 or 5 (1.8-2.2 cm$^2$). Three subjects had OLT on the medial central trochlea, and 1 had a combined medial and lateral lesions. OLT were exposed through medial malleolus osteotomy, with an additional lateral arthrotomy in the combined lesions. Bi-phasic porous osteochondral scaffolds (single implant or 2 implants) were implanted in a press-fit manner using a designated surgical toolset. Treatment outcome was followed clinically (Foot and Ankle Outcome Score, EQ-5D 3L, Tegner activity scale) and by medical imaging (radiographs, magnetic resonance imaging) from 18 to 32 months. All Foot and Ankle Outcome Score values increased from preoperative to final follow-up values (Symptoms 62 to 71, Pain 53 to 84, ADL 60 to 89, Sport 19 to 65, and QoL 18 to 47). EQ-5D 3L increased from 0.59 to 0.76, and Tegner activity values increased from 1.5 to 3. Kellgren-Lawrence ankle radiographic scores remained stable (2 to 2). Postoperative MR evaluation demonstrated cartilage defect fill of 75% to 100% respect to the native cartilage in 3 subjects (4 OLTs), while 1 lesion was filled 25% to 50%. No graft related serious adverse events or graft failures were reported. The use of a bi-phasic osteochondral biodegradable aragonite-based scaffold in the treatment of complex OLT during the reported period presented positive and promising clinical and radiologic outcome, without serious adverse events or graft failures. Agili-C™ ankle aragonite biodegradable implants bi-phasic implants cartilage osteochondral lesions scaffold talus ortopedija nartnica kirurgija osteohondralne lezije talusa true false true Angleški jezik Slovenski jezik Članek v reviji 2022-07-20 12:48:15 2022-07-20 12:48:16 2022-09-15 04:16:45 0000-00-00 00:00:00 2021 0 0 Str. 391-395 iss. 2 Vol. 60 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617.3 1067-2516 10.1053/j.jfas.2020.06.028 108232451 1-s2.0-S1067251620303380-main.pdf 1-s2.0-S1067251620303380-main.pdf 1 9BDEFAB69EAF515AAB5B04C171C25A4F 189802d9903a220640bfa953f8c669f258658b39000759ec9e7d26c599f1f43e 48659d90-081c-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=158760 https://www.sciencedirect.com/science/article/pii/S1067251620303380 0 56705c1b-0819-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=158759 Medicinska fakulteta 0 0 0