20.500.12556/RUL-138367 Urine and Fecal $^1$H-NMR metabolomes differ significantly between pre-term and full-term born physically fit healthy adult males Preterm birth (before 37 weeks gestation) accounts for ~10% of births worldwide and remains one of the leading causes of death in children under 5 years of age. Preterm born adults have been consistently shown to be at an increased risk for chronic disorders including cardiovascular, endocrine/metabolic, respiratory, renal, neurologic, and psychiatric disorders that result in increased death risk. Oxidative stress was shown to be an important risk factor for hypertension, metabolic syndrome and lung disease (reduced pulmonary function, long-term obstructive pulmonary disease, respiratory infections, and sleep disturbances). The aim of this study was to explore the differences between preterm and full-term male participants’ levels of urine and fecal proton nuclear magnetic resonance ($^1$H-NMR) metabolomes, during rest and exercise in normoxia and hypoxia and to assess general differences in human gut-microbiomes through metagenomics at the level of taxonomy, diversity, functional genes, enzymatic reactions, metabolic pathways and predicted gut metabolites. Significant differences existed between the two groups based on the analysis of $^1$H-NMR urine and fecal metabolomes and their respective metabolic pathways, enabling the elucidation of a complex set of microbiome related metabolic biomarkers, supporting the idea of distinct host-microbiome interactions between the two groups and enabling the efficient classification of samples; however, this could not be directed to specific taxonomic characteristics. premature birth $^1$H-NMR metabolomics hypoxia fecal metagenomics biomarkers activity hypoxia biokemija metabolomika prezgodnje rojstvo odrasli moški biomarkerji true false false Angleški jezik Angleški jezik Članek v reviji 2022-07-18 10:14:36 2022-07-18 10:14:39 2023-03-21 11:16:58 0000-00-00 00:00:00 2022 0 0 22 str. iss. 6, art. 536 Vol. 12 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 612 2218-1989 10.3390/metabo12060536 111333123 metabolites-12-00536.pdf metabolites-12-00536.pdf 1 3A87557A4647F25FDB1573F23F9C8B75 0149e16469195d4bdcbe9ef9d7e6dceb7023240ddce5377c53ed255aa7eed39b 58906a1e-068c-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=158663 https://www.mdpi.com/2218-1989/12/6/536 1 6d8ea77d-0671-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=158655 Biotehniška fakulteta Fakulteta za šport Medicinska fakulteta Fakulteta za elektrotehniko Fakulteta za gradbeništvo in geodezijo 0 0 0