20.500.12556/RUL-137423 Nanotechnology therapy for Alzheimer′s disease memory impairment attenuation Currently, there is no cure for Alzheimer’s disease (AD) in humans; treatment is symptomatic only. Aging of the population, together with an unhealthy diet and lifestyle, contribute to the steady, global increase of AD patients. This increase creates significant health, societal and economical challenges even for the most developed countries. AD progresses from an asymptomatic stage to a progressively worsening cognitive impairment. The AD cognitive impairment is underpinned by progressive memory impairment, an increasing inability to recall recent events, to execute recently planned actions, and to learn. These changes prevent the AD patient from leading an independent and fulfilling life. Nanotechnology (NT) enables a new, alternative pathway for development of AD treatment interventions. At present, the NT treatments for attenuation of AD memory impairment are at the animal model stage. Over the past four years, there has been a steady increase in publications of AD animal models with a wide variety of original NT treatment interventions, able to attenuate memory impairment. NT therapy development, in animal models of AD, is faced with the twin challenges of the nature of AD, a chronic impairment, unique to human, of the tau protein and A β peptides that regulate several key physiological brain processes, and the incomplete understanding of AD′s aetiology. This paper reviews the state-of-the-art in NT based treatments for AD memory impairment in animal models and discusses the future work for translation to the successful treatment of AD cognitive impairment in human. nanotechnology nano particles Alzheimer’s disease memory impairment animal models nanotehnologija nanodelci Alzheimerjeva bolezen motnje spomina živalski modeli true false true Angleški jezik Slovenski jezik Članek v reviji 2022-06-16 11:11:03 2022-06-16 11:11:51 2023-02-03 09:41:31 0000-00-00 00:00:00 2021 0 0 28 str. iss. 3, art. 1102 Vol. 22 Feb. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1422-0067 10.3390/ijms22031102 140476931 ijms-22-01102-v2_(3).pdf ijms-22-01102-v2_(3).pdf 1 3107EF01B440F49CDFC2AACF218E145E 01433ab95138764bc3920b42cd1782bb0446435cc949c56ae1ef1fa25714c10f a31d6779-ed54-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157353 https://www.mdpi.com/1422-0067/22/3/1102 0 9ba51f6f-ed54-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157352 Medicinska fakulteta 0 0 0