20.500.12556/RUL-137343 Novel and future treatment options in mesothelioma a systematic review Mesothelioma is a rare tumor, frequently associated with asbestos exposure, arising from pleura and peritoneum. Traditionally, diagnosis and treatment have been difficult in a clinical setting. The treatment is based on a trimodal approach involving surgery, chemotherapy, and radiotherapy. The introduction of chemotherapy improved the overall survival. However, the regimen of pemetrexed/cisplatin doublet has not been changed as a standard treatment since 2004. Novel combinations of ipilimumab and nivolumab have only been approved for clinical use in late 2020. The aim of this review was to systematically summarize findings on novel treatment options in mesothelioma. We searched available medical databases online, such as PubMed and Clinicaltrials.gov, to systematically review the literature on novel approaches in immunotherapy, vaccines, and Chimeric Antigen Receptor (CAR)-T cell therapy in mesothelioma. We manually screened 1127 articles on PubMed and 450 trials on ClinicalTrials.gov, and 24 papers and 12 clinical trials published in the last ten years were included in this review. Immunotherapy that was swiftly introduced to treat other thoracic malignancies was slow to reach desirable survival endpoints in mesothelioma, possibly due to limited patient numbers. Novel treatment approaches, such as CAR-T cell therapy, are being investigated. As the incidence of mesothelioma is still rising globally, novel treatment options based on a better understanding of the tumor microenvironment and the genetic drivers that modulate it are needed to support future precision-based therapies. mesothelioma chemotherapy immunotherapy gene therapy CAR-T cells vaccine therapy mezoteliom kemoterapija imunoterapija genska terapija true false true Angleški jezik Slovenski jezik Članek v reviji 2022-06-13 11:56:16 2022-06-13 11:56:21 2022-09-15 04:14:58 0000-00-00 00:00:00 2022 0 0 13 str. iss. 4, art. 1975 Vol. 23 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.2 1422-0067 10.3390/ijms23041975 97152515 ijms-23-01975-v2.pdf ijms-23-01975-v2.pdf 1 E22C469EDD70997F4796053267B55E72 6edbcf383be8d0392383fbbff38f8b0012462a95a93ff491f9c36026dbbc57d4 1cf41f99-eaff-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157261 https://www.mdpi.com/1422-0067/23/4/1975 1 e8674df9-eafe-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157260 Medicinska fakulteta 0 0 0