20.500.12556/RUL-137157 Razvoj in vrednotenje bukalnih filmov z valsartanom ter bukalnih filmov z metoklopramidom Development and evaluation of buccal films with valsartan and buccal films with metoclopramide Namen magistrske naloge je razvoj in vrednotenje bukalnih filmov, ki vsebujejo valsartana ali metoklopramid. Obe zdravilni učinkovini imata nizko biološko uporabnost po peroralni aplikaciji, ki bi jo lahko z vgradnjo v bukalni film izboljšali. Bukalne filme bomo izdelali iz različnih osnovnih raztopin ter jih s pomočjo slikovne analize razvrstili v kakovostne razrede. Primerjali bomo profile sproščanja formulacij s tremi različnimi metodami sproščanja. S pomočjo metode načrtovanja eksperimentov bomo poiskali faktorje, ki imajo pomemben vpliv na lastnosti formulacij. Metoclopramide and valsartan are active substances that have a very low bioavailability after oral administration. In order to increase bioavailability new delivery systems are being developed including buccal films. As part of the master's thesis, we studied the influence of individual excipients on the mechanical properties of films and the rate of release of the active ingredient from them.The formulations that exhibited the desired properties were released on three different devices and the results were compared with each other. Thereupon we evaluated the quality of the films using image analysis. We also used the MODDE program and focused our search on factors that have a significant influence on the properties of the formulations. bukalni filmi valsartan metoklopramid sproščanje mehčala načrtovanje eksperimentov slikovna analiza buccal films valsartan metoclopramide release plasticizers experimental design image analysis. true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2022-06-03 08:45:18 2022-06-03 08:45:21 2022-09-15 04:14:42 0000-00-00 00:00:00 2022 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 87047 7531.pdf 7531.pdf 1 061212024CA16461FBAADC8DDAF3F836 bc3888a77eeab3f47b67dbd8f756d0d17e574c4e68e72f79948fb076ad48632d 962a32a7-e308-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157020 Fakulteta za farmacijo 0 0 0