20.500.12556/RUL-137124 The role of vitamin A in retinal diseases Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is essential for several physiological processes. Either hyper- or hypovitaminosis can be harmful. One of the most important vitamin A functions is its involvement in visual phototransduction, where it serves as the crucial part of photopigment, the first molecule in the process of transforming photons of light into electrical signals. In this process, large quantities of vitamin A in the form of 11-cis-retinal are being isomerized to all-trans-retinal and then quickly recycled back to 11-cis-retinal. Complex machinery of transporters and enzymes is involved in this process (i.e., the visual cycle). Any fault in the machinery may not only reduce the efficiency of visual detection but also cause the accumulation of toxic chemicals in the retina. This review provides a comprehensive overview of diseases that are directly or indirectly connected with vitamin A pathways in the retina. It includes the pathophysiological background and clinical presentation of each disease and summarizes the already existing therapeutic and prospective interventions. vitamin A retinal diseases ABCA4 visual cycle RHO RDH5 RDH12 treatment vitamin A bolezni mrežnice ABCA4 true false true Angleški jezik Slovenski jezik Članek v reviji 2022-06-01 13:32:00 2022-06-01 13:32:01 2022-09-15 04:14:39 0000-00-00 00:00:00 2022 0 0 27 str. iss. 3, art. 1014 Vol. 23 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617.7 1422-0067 10.3390/ijms23031014 97200131 ijms-23-01014-v2.pdf ijms-23-01014-v2.pdf 1 E0A1842CFBE77F7ED8D1CFAFA2747632 c581bc60d43d029b7028c68fb9550d2ad1e1bba8985cf93437f5e65720e05b1b 92e1a197-e19e-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156964 https://www.mdpi.com/1422-0067/23/3/1014 1 4fb7bbc4-e19e-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156963 Medicinska fakulteta 0 0 0