20.500.12556/RUL-136783 Causation of oxidative stress and defense response of a yeast cell model after treatment with orthodontic alloys consisting of metal ions Misaligned teeth have a tremendous impact on oral and dental health, and the most efficient method of correcting the problem is orthodontic treatment with orthodontic appliances. The study was conducted to investigate the metal composition of selected orthodontic alloys, the release of metal ions, and the oxidative consequences that the metal ions may cause in the cell. Different sets of archwires, stainless steel brackets, and molar bands were incubated in artificial saliva for 90 days. The composition of each orthodontic material and quantification of the concentration of metal ions released were evaluated. Metal ion mixtures were prepared to determine the occurrence of oxidative stress, antioxidant enzyme defense system, and oxidative damage to proteins. The beta titanium alloy released the fewest metal ions and did not cause oxidative stress or protein damage. The metal ions from stainless steel and the cobalt-chromium alloy can cause oxidative stress and protein damage only at high concentrations. All metal ions from orthodontic alloys alter the activity of antioxidant enzymes in some way. The determined amounts of metal ions released from orthodontic appliances in a simulated oral environment are still below the maximum tolerated dose, and the concentrations of released metal ions are not capable of inducing oxidative stress, although some changes in antioxidant enzyme activity were observed at these concentrations. orthodontic appliance metal ion release oxidative stress ROS antioxidative defense ortodontski pripomočki oksidativni stres kovinski ioni vpliv na zdravje antioksidanti true false true Angleški jezik Slovenski jezik Članek v reviji 2022-05-20 12:31:51 2022-05-20 12:31:57 2022-09-15 04:14:19 0000-00-00 00:00:00 2022 0 0 24 str. iss. 1, art. 63 Vol. 11 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.314-089.23:546.7:66.094.3.097.8 2076-3921 10.3390/antiox11010063 91359235 antioxidants-11-00063.pdf antioxidants-11-00063.pdf 1 DFD8753FBF58A30B77E736CADBCE71A1 664f8a5e31b97cb8c0b1c2143fd795bb7d68648c9367ca6b7148901290efa9b3 3e94376e-d828-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156569 https://www.mdpi.com/2076-3921/11/1/63 1 f4c3f976-d827-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156568 Zdravstvena fakulteta Medicinska fakulteta Biotehniška fakulteta 0 0 0