20.500.12556/RUL-136713 Treatment of benign prostatic hyperplasia by natural drugs Benign prostatic hyperplasia (BPH) is one of the most common urinary diseases affecting men, generally after the age of 50. The prevalence of this multifactorial disease increases with age. With aging, the plasma level of testosterone decreases, as well as the testosterone/estrogen ratio, resulting in increased estrogen activity, which may facilitate the hyperplasia of the prostate cells. Another theory focuses on dihydrotestosterone (DHT) and the activity of the enzyme 5α-reductase, which converts testosterone to DHT. In older men, the activity of this enzyme increases, leading to a decreased testosterone/DHT ratio. DHT may promote prostate cell growth, resulting in hyperplasia. Some medicinal plants and their compounds act by modulating this enzyme, and have the abovementioned targets. This review focuses on herbal drugs that are most widely used in the treatment of BPH, including pumpkin seed, willow herb, tomato, maritime pine bark, Pygeum africanum bark, rye pollen, saw palmetto fruit, and nettle root, highlighting the latest results of preclinical and clinical studies, as well as safety issues. In addition, the pharmaceutical care and other therapeutic options of BPH, including pharmacotherapy and surgical options, are discussed, summarizing and comparing the advantages and disadvantages of each therapy. benign prostatic hyperplasia medicinal plants phytotherapy saw palmetto preclinical studies clinical efficacy safety issues predklinične študije klinična učinkovitost varnostne težave true false true Angleški jezik Slovenski jezik Članek v reviji 2022-05-17 09:28:26 2022-05-17 09:28:30 2023-05-05 09:07:30 0000-00-00 00:00:00 2021 0 0 32 str. iss. 23, art. 7141 Vol. 26 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.65-007.61 1420-3049 10.3390/molecules26237141 86644739 molecules-26-07141-v2.pdf molecules-26-07141-v2.pdf 1 15770863F1F4C399C9B5072BAAACDB5F 5184870d2e4dd98ba23131942b292460237474fd2b9bf64d342a1322207e63a0 23c5dd5d-d5b3-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156465 https://www.mdpi.com/1420-3049/26/23/7141 1 d6a23e49-d5b2-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156464 Fakulteta za farmacijo 0 0 0