20.500.12556/RUL-136598 Is it possible to predict clonal thrombocytosis in triple-negative patients with isolated thrombocytosis based only on clinical or blood findings? JAK2, MPL, and CALR mutations define clonal thrombocytosis in about 90% of patients with sustained isolated thrombocytosis. In the remainder of patients (triple-negative patients) diagnosing clonal thrombocytosis is especially difficult due to the different underlying conditions and possible inconclusive bone marrow biopsy results. The ability to predict patients with sustained isolated thrombocytosis with a potential clonal origin has a prognostic value and warrants further examination. The aim of our study was to define a non-invasive clinical or blood parameter that could help predict clonal thrombocytosis in triple-negative patients. We studied 237 JAK2 V617-negative patients who were diagnosed with isolated thrombocytosis and referred to the haematology service. Sixteen routine clinical and blood parameters were included in the logistic regression model which was used to predict the type of thrombocytosis (reactive/clonal). Platelet count and lactate dehydrogenase (LDH) were the only statistically significant predictors of clonal thrombocytosis. The platelet count threshold for the most accurate prediction of clonal or reactive thrombocytosis was 449 × 10$^9$/L. Other tested clinical and blood parameters were not statistically significant predictors of clonal thrombocytosis. The level of LDH was significantly higher in CALR-positive patients compared to CALR-negative patients. We did not identify any new clinical or blood parameters that could distinguish clonal from reactive thrombocytosis. When diagnosing clonal thrombocytosis triple-negative patients are most likely to be misdiagnosed. Treatment in patients with suspected triple-negative clonal thrombocytosis should not be delayed if cardiovascular risk factors or pregnancy coexist, even in the absence of firm diagnostic criteria. In those cases the approach “better treat more than less” should be followed. clonal thrombocytosis essential thrombocythaemia lactate dehydrogenase calreticulin platelet count klonska trombocitoza esencialna trombocitemija laktat dehidrogenaza true false true Angleški jezik Slovenski jezik Članek v reviji 2022-05-12 10:54:48 2022-05-12 10:54:55 2022-09-15 04:14:03 0000-00-00 00:00:00 2021 0 0 13 str. iss. 24, art. 5803 Vol. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2077-0383 10.3390/jcm10245803 92226819 jcm-10-05803-v2.pdf jcm-10-05803-v2.pdf 1 0EBF79A5CC174557DEB55C2764805746 5115b73b4ac6ac7909811a1d31b9e5e03f4e11138d910bd6b616b756dc4a1981 6db6dcdf-d1d1-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156310 https://www.mdpi.com/2077-0383/10/24/5803 1 1688f16b-d1d1-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156309 Medicinska fakulteta 0 0 0