20.500.12556/RUL-136594 Highly sensitive amperometric detection of hydrogen peroxide in saliva based on N-doped graphene nanoribbons and MnO$_2$ modified carbon paste electrodes Four different graphene-based nanomaterials (htGO, N-htGO, htGONR, and N-htGONR) were synthesized, characterized, and used as a modifier of carbon paste electrode (CPE) in order to produce a reliable, precise, and highly sensitive non-enzymatic amperometric hydrogen peroxide sensor for complex matrices. CPE, with their robustness, reliability, and ease of modification, present a convenient starting point for the development of new sensors. Modification of CPE was optimized by systematically changing the type and concentration of materials in the modifier and studying the prepared electrode surface by cyclic voltammetry. N-htGONR in combination with manganese dioxide (1:1 ratio) proved to be the most appropriate material for detection of hydrogen peroxide in pharmaceutical and saliva matrices. The developed sensor exhibited a wide linear range (1.0–300 µM) and an excellent limit of detection (0.08 µM) and reproducibility, as well as high sensitivity and stability. The sensor was successfully applied to real sample analysis, where the recovery values for a commercially obtained pharmaceutical product were between 94.3% and 98.0%. Saliva samples of a user of the pharmaceutical product were also successfully analyzed. electrochemical sensors hydrogen peroxide graphene graphene nanoribbons amperometry elektrokemijski senzorji vodikov peroksid grafen grafenski nanotrakovi amperometrija true false true Angleški jezik Slovenski jezik Članek v reviji 2022-05-12 09:38:39 2022-05-12 09:38:40 2022-09-15 04:14:03 0000-00-00 00:00:00 2021 0 0 13 str. iss. 24, art. 8301 Vol. 21 Dec. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 543.553 1424-8220 10.3390/s21248301 89121539 sensors-21-08301-v2.pdf sensors-21-08301-v2.pdf 1 2CCCA07AA054CB915C5BEE490D3B4E25 66313459ddc5ee98e88f7fac43947a0eef3ffd899e8644712cfb367c5ca080c5 a7b4bdfb-d1c6-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156304 https://www.mdpi.com/1424-8220/21/24/8301 1 6f8f8082-d1c6-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156303 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0