20.500.12556/RUL-136570 Drug delivery strategies for curcumin and other natural Nrf2 modulators of oxidative stress-related diseases Oxidative stress is associated with a wide range of diseases characterised by oxidant-mediated disturbances of various signalling pathways and cellular damage. The only effective strategy for the prevention of cellular damage is to limit the production of oxidants and support their efficient removal. The implication of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the cellular redox status has spurred new interest in the use of its natural modulators (e.g., curcumin, resveratrol). Unfortunately, most natural Nrf2 modulators are poorly soluble and show extensive pre-systemic metabolism, low oral bioavailability, and rapid elimination, which necessitates formulation strategies to circumvent these limitations. This paper provides a brief introduction on the cellular and molecular mechanisms involved in Nrf2 modulation and an overview of commonly studied formulations for the improvement of oral bioavailability and in vivo pharmacokinetics of Nrf2 modulators. Some formulations that have also been studied in vivo are discussed, including solid dispersions, self-microemulsifying drug delivery systems, and nanotechnology approaches, such as polymeric and solid lipid nanoparticles, nanocrystals, and micelles. Lastly, brief considerations of nano drug delivery systems for the delivery of Nrf2 modulators to the brain, are provided. The literature reviewed shows that the formulations discussed can provide various improvements to the bioavailability and pharmacokinetics of natural Nrf2 modulators. This has been demonstrated in animal models and clinical studies, thereby increasing the potential for the translation of natural Nrf2 modulators into clinical practice. Nrf2 modulator oxidative stress oral bioavailability poor solubility curcumin resveratrol solid dispersions SMEDDS nanoparticles micelles Nrf2 modulator peroralna biološka uporabnost slaba topnost kurkumin resveratrol trdne disperzije nanodelci micele samo(mikro)emulgirajoči sistem oksidativni stres true false true Angleški jezik Slovenski jezik Članek v reviji 2022-05-11 14:22:54 2022-05-11 14:22:59 2022-09-15 04:14:01 0000-00-00 00:00:00 2021 0 0 29 str. iss. 12, art. 2137 Vol. 13 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 542:612.015 1999-4923 10.3390/pharmaceutics13122137 89011971 pharmaceutics-13-02137.pdf pharmaceutics-13-02137.pdf 1 AF0218C3DABCD270E800BFEC8CA195B1 c8678f9afb9656796bbf34b0d084c26fdd6d296e60007861ff41e422afbecff3 42a32414-d125-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156276 https://www.mdpi.com/1999-4923/13/12/2137 0 fd9fa96c-d124-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156275 Fakulteta za farmacijo 0 0 0