20.500.12556/RUL-136542 Basic exploratory study of bisphenol A (BPA) dietary administration to Istrian Pramenka rams and male toxicity investigation Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months to 25 ug/kg body weight (low dose) of BPA affects spermatogenesis or sperm quality in young Istrian Pramenka rams exposed via diet. We evaluated body and testicular weights, histopathology of testes and epididymides, and sperm analyses, and compared these parameters between the group of treated rams and the control group of rams. Although there were some differences between the two groups, these differences were not large or statistically significant. The only statistically significant difference was the lower epithelial height of seminiferous tubules in treated rams, compared to control rams. In addition to assessing toxicity, BPA concentrations in the blood plasma of treated rams were determined after the first administration, and the toxicokinetic parameters of total BPA were calculated. In this study, no major signs of altered reproduction in rams were detected. bisphenol A rams toxicokinetics male toxicity sperm true false true Angleški jezik Ni določen Članek v reviji 2022-05-10 12:36:37 2022-05-10 12:36:42 2022-09-15 04:13:58 0000-00-00 00:00:00 2022 0 0 17 str. no. 5, art. 224 Vol. 10 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 636.09:615.9 2305-6304 10.3390/toxics10050224 107203843 Basic-Sturm.pdf Basic-Sturm.pdf 1 E9A5B285F9A09ABFD680366E76787831 d6ea0789aaee8ffdcfd3ad97fb45b70c788d570428b6dd9fcd155cd48eb05a18 a33108b6-d04d-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156235 https://www.mdpi.com/2305-6304/10/5/224 1 fb7709ca-d04c-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156233 Veterinarska fakulteta 0 0 0