20.500.12556/RUL-136421 Bio-performance of hydrothermally and plasma-treated titanium the new generation of vascular stents The research presented herein follows an urgent global need for the development of novel surface engineering techniques that would allow the fabrication of next-generation cardiovascular stents, which would drastically reduce cardiovascular diseases (CVD). The combination of hydrothermal treatment (HT) and treatment with highly reactive oxygen plasma (P) allowed for the formation of an oxygen-rich nanostructured surface. The morphology, surface roughness, chemical composition and wettability of the newly prepared oxide layer on the Ti substrate were characterized by scanning electron microscopy (SEM) with energy-dispersive X-ray analysis (EDX), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and water contact angle (WCA) analysis. The alteration of surface characteristics influenced the material’s bio-performance; platelet aggregation and activation was reduced on surfaces treated by hydrothermal treatment, as well as after plasma treatment. Moreover, it was shown that surfaces treated by both treatment procedures (HT and P) promoted the adhesion and proliferation of vascular endothelial cells, while at the same time inhibiting the adhesion and proliferation of vascular smooth muscle cells. The combination of both techniques presents a novel approach for the fabrication of vascular implants, with superior characteristics. cardiovascular disease metallic stents hydrothermal treatment non-thermal plasma treatment TiO$_2$ true false true Angleški jezik Ni določen Članek v reviji 2022-05-03 11:50:25 2022-05-03 11:50:25 2022-09-15 04:13:51 0000-00-00 00:00:00 2021 0 0 14 str. iss. 21, art. 11858 Vol. 22 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 53 1422-0067 10.3390/ijms222111858 83075331 ijms-22-11858.pdf ijms-22-11858.pdf 1 5EE58CC647FA5582B6289D83AFA1962E 7e30fa329b52a1862575690e48a58bafdfd3a49adc96ec97b6f15733571961bb 9e055ff1-cac6-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156061 https://www.mdpi.com/1422-0067/22/21/11858 0 7b618a9a-cac6-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=156060 Fakulteta za elektrotehniko Medicinska fakulteta 0 0 0