20.500.12556/RUL-136370 Ozonation of amoxicillin and ciprofloxacin in model hospital wastewater to increase biotreatability Amoxicillin (AMX) and Ciprofloxacin (CIP) are antibiotics commonly used in human medicine with high environmental toxicity and poor biodegradability. They have been found in various hospital effluents and groundwater, and their environmental impact is still not fully understood. In this work, we investigated the possibility of treating model wastewaters containing the antibiotics AMX and CIP using ozonation, with the addition of H$_2$O$_2$ under various conditions, including different pH values, H$_2$O$_2$, and ozone dosages. The quantification of and treatment efficacy for antibiotic removal were determined via solid phase extraction followed by chromatographic separation by liquid chromatography coupled with tandem triple quadrupole mass spectrometry (LC/MS/MS). This analytical system is quite efficient for the detection of all major antibiotic classes, even if they are present at very low concentrations. The efficiency of ozonation was determined by measuring the TOC (Total Organic Carbon) changes after ozonation of the model wastewater and by measuring the concentration of the two antibiotics. In a sequential activated sludge process of ozone-treated model wastewater, almost complete TOC removal and an overwhelming decrease in antibiotic concentrations (up to 99%) were observed. Ozonation resulted in complete removal of AMX and CIP in less than 30 and 120 min, respectively. The results of this work indicate that ozonation could be a suitable pretreatment method to reduce the toxicity of contaminants (AMX and CIP) and improve the biodegradability of hospital wastewater. antibiotics amoxicillin (AMX) ciprofloxacin (CIP) hospital wastewater hydrogen peroxide ozone water treatment sludge treatment antibiotiki amoksicilin ciprofloksacin bolnišnične odpadne vode ozon vodikov peroksid čiščenje vod true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-26 15:16:41 2022-04-26 15:16:41 2022-09-15 04:13:48 0000-00-00 00:00:00 2021 0 0 13 str. iss. 11, art. 1407 Vol. 10 Nov. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 628.349:66.094.3-926.214:615.33 2079-6382 10.3390/antibiotics10111407 85418243 antibiotics-10-01407.pdf antibiotics-10-01407.pdf 1 C70E1C59DA5596ED0DD9A17F204DDB29 08638fad3890da688d5be20a16a1d06ad2cef732d347915af75d83befdc89837 752ce438-c563-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155988 https://www.mdpi.com/2079-6382/10/11/1407 0 0a6ad445-c563-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155987 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0