20.500.12556/RUL-136270 Estrogens and the Schrödinger's cat in the ovarian tumor microenvironment Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the “Schrödinger’s cat” thought experiment, the context-dependent constituents of the—by the time of diagnosis—well-established tumor microenvironment may display a tumor-protective and -destructive role. Systemic and locally synthesized estrogens contribute to the formation of a pro-tumoral microenvironment that enables the sustained tumor growth, invasion and metastasis. Here we focus on the estrogen biosynthetic and metabolic pathways in ovarian cancer and elaborate their actions on phenotypically plastic, estrogen-responsive, aging immune cells of the tumor microenvironment, altogether highlighting the multicomponent-connectedness and complexity of cancer, and contributing to a broader understanding of the ovarian cancer biology. ovarian cancer estrogens immunosuppressive microenvironment plasticity rak jajčnikov estrogeni imunosupresivno mikrookolje true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-21 14:32:17 2022-04-21 14:32:18 2022-09-15 04:13:40 0000-00-00 00:00:00 2021 0 0 17 str. iss. 19, art. 5011 Vol. 13 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 2072-6694 10.3390/cancers13195011 79662851 cancers-13-05011-v2.pdf cancers-13-05011-v2.pdf 1 836ADCDD738371386E58E6CA2F4CDD18 75c1801ca8f1be21e672833f8c35a6d30de2e4b13b86bff19bbb1683a812a648 6266bee6-c16f-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155822 https://www.mdpi.com/2072-6694/13/19/5011 1 04330616-c16f-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155821 Medicinska fakulteta 0 0 0