20.500.12556/RUL-136224 Diverse mechanisms of antimicrobial activities of lactoferrins, lactoferricins, and other lactoferrin-derived peptides Lactoferrins are an iron-binding glycoprotein that have important protective roles in the mammalian body through their numerous functions, which include antimicrobial, antitumor, anti-inflammatory, immunomodulatory, and antioxidant activities. Among these, their antimicrobial activity has been the most studied, although the mechanism behind antimicrobial activities remains to be elucidated. Thirty years ago, the first lactoferrin-derived peptide was isolated and showed higher antimicrobial activity than the native lactoferrin lactoferricin. Since then, numerous studies have investigated the antimicrobial potencies of lactoferrins, lactoferricins, and other lactoferrin-derived peptides to better understand their antimicrobial activities at the molecular level. This review defines the current antibacterial, antiviral, antifungal, and antiparasitic activities of lactoferrins, lactoferricins, and lactoferrin-derived peptides. The primary focus is on their different mechanisms of activity against bacteria, viruses, fungi, and parasites. The role of their structure, amino-acid composition, conformation, charge, hydrophobicity, and other factors that affect their mechanisms of antimicrobial activity are also reviewed. lactoferrin lactoferricin peptides antimicrobial activity mechanisms of action bioaktivni peptidi laktoferin protimikrobno delovanje true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-20 13:25:38 2022-04-20 13:25:39 2022-09-15 04:13:35 0000-00-00 00:00:00 2021 0 0 28 str. iss. 20, art. 11264 Vol. 22 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.112:579.2 1422-0067 10.3390/ijms222011264 81567491 ijms-22-11264-v2.pdf ijms-22-11264-v2.pdf 1 A415782A8902200756E5F78F58F6BA5D 279b81cfed249fd369e1823012be710d03ce9ba8845f7bcb7337080b28f2db5e c7128c6d-c09c-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155757 https://www.mdpi.com/1422-0067/22/20/11264 1 8a584189-c09c-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155756 Biotehniška fakulteta 0 0 0