20.500.12556/RUL-136081 A review and evaluation of the data supporting internal use of Helichrysum italicum Helichrysum italicum is a Mediterranean plant with various pharmacological activities. Despite extensive reports on the bioactivity of the plant, its clinically studied applications have not yet been reviewed. The aim of our study was to gather information on the internal use of H. italicum and its bioactive constituents to determine its efficacy and safety for human use. We reviewed research articles that have not been previously presented in this context and analyzed relevant clinical studies with H. italicum. Cochranelibrary.com revealed six eligible clinical trials with H. italicum that examined indications for pain management, cough, and mental exhaustion. Although the efficacy of H. italicum has been demonstrated both in in vitro tests and in humans, it is difficult to attribute results from clinical trials to H. italicum alone, as it has usually not been tested as the sole component. On the other hand, clinical trials provide positive information on the safety profile since no adverse effects have been reported. We conclude that H. italicum is safe to use internally, while new clinical studies with H. italicum as a single component are needed to prove its efficacy. Based on the recent trend in H. italicum research, further studies are to be expected. Helichrysum italicum biological activity internal use clinical studies Helichrysum italicum biološka aktivnost klinične študije true false true Angleški jezik Slovenski jezik Članek v reviji 2022-04-11 10:51:12 2022-04-11 10:51:13 2022-09-15 04:13:22 0000-00-00 00:00:00 2021 0 0 17 str. iss. 8, art. 1738 Vol. 10 Avg. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 633.812:613.2 2223-7747 10.3390/plants10081738 76122627 RAZ_Kramberger_Katja_2021.pdf RAZ_Kramberger_Katja_2021.pdf 1 64C7E0BEA52EA246CC16CB8E12CA3B95 c6fda9e24af5143587f099f86180e4bc90627b755db3e2c46cb0657a8d337d4d d41b50a0-b974-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155534 https://www.mdpi.com/2223-7747/10/8/1738 0 a78b87a4-b974-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=155533 Medicinska fakulteta Fakulteta za farmacijo 0 0 0